Effects of rebamipide on healing of low-dose aspirin-induced small intestinal mucosal injury- A pilot study
- Conditions
- small intestinal injury
- Registration Number
- JPRN-UMIN000003463
- Lead Sponsor
- Osaka City University Graduate School of Medicine Osaka Medical College Kyoto Prefectural University of Medicine Saga University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 45
Not provided
1) Subjects with the diseases which induce small intestinal injury such as Chrohn's disease, gastrointestinal stromal tumor, small intestinal tumor. 2) The subject taking drugs which have potential to induce small intestinal injury such as NSAIDs, anticancer drugs. 3) The subject taking antibiotics, sulfasalazine, prostaglandin analog, corticosteroids, free radical depressant, elastase depressant, mucoprotective drugs and drugs which have potential to improve small intestinal injury. 4) The subject having evident small intestinal bleeding. 5) The subjects having diverticula and diaphragm-like stenosis in the small intestine. 6) The subject who have renal and hepatic disfunction. 7) The subjects who has allergic hypersensitivity against rebamipide. 8) The subject who participate in other clinical studies within 4 weeks. 9) The subjects who are judged to be inappropriate for this study by doctors conducting the study.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Capsule endoscopic findings (number of ulcers/erosions)
- Secondary Outcome Measures
Name Time Method ewis Score Symptom assessment (anemia, melena, complications) Safety