S?tudy of the theraputic effect of low dose aspirin on symptoms of chronic rhinosinusitis and nasal polyposis with aspirin sensitivity
- Conditions
- Chronic rhinosinusitis with nasal polyposis.Other polyp of sinus Polyp of sinus: accessory ethmoidal maxillary sphenoida
- Registration Number
- IRCT2015061522531N2
- Lead Sponsor
- Vice chancellor for research, Iran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 60
age of 18-65 years; achieving a course of three months of conventional treatment before aspirin challenge; presence of symptoms of chronic rhinosinusitis with nasal polyposis confirmed by CT scan;
Exclusion criteria: presence of any serious underlying disease including hemorrhagic; gastrointestinal; rheumatologic; malignant; cardiovascular; renal; hepatic and psychological disorders; history of IgE mediated reactions to aspirin or other non steroidal anti inflammatory drugs; first second expiratory volume of less than 70 percent of predicted at the time of aspirin challenge; pregnancy; nursing; use of topical or systemic beta blockers; warfarin and its derivates; Angiotensin converting enzyme inhibitors; patients with poor cooperation or treatment adherence; patients with carriers with high risk of trauma and accidents;
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Severity of symptoms of chronic rhinosinusitis with nasal polyposis. Timepoint: before intervention, three months and six minths after intervention. Method of measurement: SinoNasal Outcome Test questionnaire and paranasa sinus CT scan.
- Secondary Outcome Measures
Name Time Method Complications of aspirin including gastrointestinal dyscomfort, epigastric pain or burning, nausea, vomitting, gastro intestinal bleeding, easy bruising, bleeding with minor trauma. Timepoint: before intervention, three and six months after intervention. Method of measurement: history taking and physical examination.