Association of Salivary Proline-Rich Proteins With Progression of Atherosclerosis in Patients With Cardiovascular Diseases
Not Applicable
Recruiting
- Conditions
- Patients with cardiovascular diseases
- Registration Number
- JPRN-UMIN000048098
- Lead Sponsor
- Department of Cardiovascular Medicine, Shinshu University School of Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 1000
Inclusion Criteria
Not provided
Exclusion Criteria
1. Patients who cannot provide saliva 2. Patients who do not provide informed consent 3. Patients undergoing hemodialysis 4. Patients who are considered inappropriate for the study by the research medical doctor
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Association between salivary hPRB1 level and clinical data at admission.
- Secondary Outcome Measures
Name Time Method Clinical outcomes (major adverse cardiovascular events, death, cardiovascular death, non-cardiovascular death, myocardial infarction, stent thrombosis, revascularization, cerebrovascular event, heart failure admission, bleeding, acute renal failure, amputation) Relationship between and salivary hPRB1 concentrations and aortic calcification. Relationship between salivary hPRB1 concentrations and MAC. Relationship between salivary hPRB1 concentrations and coronary artery calcification. Relationship between salivary hPRB1 concentrations and arterial stiffness. Overall and sub-group analyses stratified by HFpEF, AF, TAVI, PCI, EVT, and ablation for AF.