The protective effect of a nasal corticosteroid (Avamys) on exercise induced airway obstruction in cold air.
Phase 4
Completed
- Conditions
- Exercise induced airway obstructionExercise Induced Athma10006436
- Registration Number
- NL-OMON33344
- Lead Sponsor
- Medisch Spectrum Twente
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 91
Inclusion Criteria
Children (12-17 years) with a history of allergic asthma
Able to perform reproducible lung function tests
FEV1>70% of predicted
Clinically stable for 3 weeks
Exclusion Criteria
Use of nasal/systemic steroids
Use of bronchodilators before testing
Other cardiac or pulmonary disease
Signs of gastro-oesophagal reflux
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Analyze the reduction in exercise induced fall of FEV1 and MIF50 after three<br /><br>weeks of treatment with fluticasone furoate.</p><br>
- Secondary Outcome Measures
Name Time Method <p>•Analyze the reduction in exercise induced increase of airway resistance,<br /><br>measured with the FOT, after three weeks of treatment with fluticasone furoate.<br /><br>•Analyze the reduction in exercise induced decrease of airway reactance,<br /><br>measured with the FOT, after three weeks of treatment with fluticasone furoate.<br /><br>•Analyze the reduction in FeNO, measured with the FOT, after three weeks of<br /><br>treatment with fluticasone furoate.<br /><br>•Analyze the increase in quality of life, measured with the PAQLQ, after three<br /><br>weeks of treatment with fluticasone furoate.<br /><br>•Analyze the increase in control of asthma, measured with the ACQ, after three<br /><br>weeks of treatment with fluticasone furoate.</p><br>