Adjunctive Right Atrial Ablation for Persistent Atrial Fibrillation With Right Atrial Enlargement

Completed

• Conditions: Persistent Atrial Fibrillation; Right Atrial Enlargement
• Interventions: Procedure: Circumferential pulmonary vein isolation + linear ablation + bi-atrial mapping + left atrial driver ablation + right atrial driver ablation; Procedure: Circumferential pulmonary vein isolation + linear ablation + bi-atrial mapping + left atrial driver ablation

• Registration Number: NCT05227586
• Lead Sponsor: Shanghai Chest Hospital

Brief Summary

This is retrospective cohort study testing whether patients with persistent atrial fibrillation and right atrial enlargement may benefit from adjunctive right atrial ablation.

Detailed Description

This is retrospective cohort study testing whether patients with persistent atrial fibrillation and right atrial enlargement may benefit from adjunctive RA ablation.

We enrolled 65 patients with persistent atrial fibrillation and right atrial enlargement received adjunctive right atrial ablation. These patients were 1:2 match with 130 patients received left atrial ablation only. Atrial fibrillation recurrence rate and other paremeters were analyzed to evaluate the efficacy of adjunctive right atrial ablation in this subset of patients.

Study Timeline

• Study Start: 2021-11-01
• Status Verified: 2022-01
• Primary Completion: 2022-01-01
• Study Completion: 2022-01-20
• Study First Submitted: 2022-01-26
• Study First Submitted QC: 2022-01-26
• Last Update Submitted: 2022-01-26
• Study First Posted: 2022-02-07
• Last Update Posted: 2022-02-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 195

Inclusion Criteria

1. Aged 18 to 80 years old;
2. Persistent AF with right atrial enlargement;
3. Nonresponse or intolerance to ≥1 antiarrhythmic drug.

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Exclusion Criteria

1. History of catheter ablation;
2. valvular heart disease;
3. hypertrophic cardiomyopathy or dilated cardiomyopathy;
4. Without follow-up data

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
LA + RA ablation	Circumferential pulmonary vein isolation + linear ablation + bi-atrial mapping + left atrial driver ablation + right atrial driver ablation	Patients with persistent atrial fibrillation and right atrial enlargement received adjunctive right atrial ablation when left atrial ablation did not terminate atrial fibrillation.
LA ablation only	Circumferential pulmonary vein isolation + linear ablation + bi-atrial mapping + left atrial driver ablation	Patients with persistent atrial fibrillation and right atrial enlargement received left atrial ablation only

Primary Outcome Measures

Name	Time	Method
atrial fibrillation (AF) recurrence rate	at 12 months post procedure	AF recurrence is defined as presence of documented AF episodes of 30 seconds or longer duration

Secondary Outcome Measures

Name	Time	Method
atrial fibrillation (AF)/atrial flutter (AFL)/atrial tachycardia (AT) recurrence rate	at 12 months post procedure	AF/AFL/AT recurrence is defined as presence of documented AF/AFL/AT episodes of 30 seconds or longer duration

Trial Locations

Locations (1)

Mu Qin; 🇨🇳 Shanghai, China