Reference values of HEPcidin Plus other Iron paramEters in childre

Completed

• Conditions: niet van toepassing: referentiewaardenstudie; 10018849

• Registration Number: NL-OMON42321
• Lead Sponsor: Maxima Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2018-04-01
• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 173

Inclusion Criteria

* Age 6 months to 18 years
* Western-European descent ((Non- Western European people may be a carrier of alpha or beta thalassemia, which may influence the results of serum hepcidin and other iron parameters)
* Infusion or venipuncture required for surgery or diagnostic
* Informed consent obtained from parents and from both parents and child in case the patient is (over)
12 years

Exclusion Criteria

* Exprematurity (gestation <37 weeks), exdismaturity (birth weight * (status after) systemic underlying disease (malignancy, asthma, diabetes, congenital heart disease, kidney failure, congenital immunodeficiencies, etc.
* Known anemia
* Treatment with iron preparations
* Acute infection
* Trauma <48 hours ago
* Operation <48 hours ago
* Use of any medication
* If the laboratory results demonstrate increased inflammation parameters, the patient will be excluded afterwards

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>* To determine age-and sex-dependent reference values of the iron regulatory<br /><br>hormone hepcidin.<br /><br>* To determine age-and sex-dependent reference values of newer iron parameters,<br /><br>such as soluble Transferrin Receptor (sTfR), reticulocyte hemoglobin content<br /><br>(Ret-Hb), and Hb Erythrocytes (RBC Hb)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>not applicable</p><br>