The value of new and functional iron status indicators to guide iron supplementation in anemia of inflammatio

Recruiting

Conditions: ferriprive anemia
iron deficiency anemia
10002086

Registration Number: NL-OMON36019

Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 40

Inclusion Criteria

-above 18 years old
-an active chronic inflammatory or infectious disorder with CRP >10 mg/L (defined by the treating medical specialist)
- anemia (defined as hemoglobin concentration below 7.0 mmol/l and 7.5 mmol/l for women and male, respectively).

Exclusion Criteria

-not able to take oral medication
-using iron supplements in the previous month
-using erythropoietin
-requiring blood transfusion
-renal and liverfailure

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameter is to determine whether the change in Ret- He, RBC- He<br /><br>and hepcidin concentration from baseline to one or two weeks iron supplemental<br /><br>therapy predicts the increase in hemoglobin concentration after 6 weeks of oral<br /><br>iron supplementation therapy;</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary objectives are to (1) assess the predicting value of Ret- He, RBC- He<br /><br>and hepcidin concentration at baseline (before therapy) to increase the<br /><br>hemoglobin concentration after six weeks of oral iron supplementation therapy;<br /><br>(2) to compare the value of conventional iron status parameters ferritin,<br /><br>transferrin saturation, soluble transferrin receptor and iron with the novel<br /><br>iron parameters to predict the response of one, two and six weeks oral iron<br /><br>supplementation therapy defined by an increase in hemoglobin concentration.</p><br>