Impact of dietary fibre on the production of beef intake biomarkers for a better assessment of food intake
Not Applicable
- Conditions
- healthy volunteers
- Registration Number
- DRKS00021291
- Lead Sponsor
- ZIEL - Insitute for Food and Health
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 13
Inclusion Criteria
healthy women and men with an age between 18 and 40
- bmi in the range of 17-30 kg/m2
- non smokers
- written informed consent
Exclusion Criteria
- Smoker
- Diseases that affects nutrient resorption, digestion, metabolism and excretion
- Chronical illness (e.g. hepatitis B/C, diabetes mellitus)
- Acute infectious disease
- Antibiotic intake during the last 6 months
- Regular medication (excluded: oral contraceptives)
- Pregnant women and nursing mothers
- Allergies and intolerances against one of the tested foods
- Diverticulosis, obstipation during anamnesis
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary outcome of this exploratory study is to investigate the impact of dietary fibres on the production of beef intake biomarkers (in particular TMAO) with targeted metabolomic methods. The primary target value is therefore the plasma TMAO level.
- Secondary Outcome Measures
Name Time Method Secondary outcome is to investigate alterations in the microbiom composition in stool samples which may occur due to high amount of dietary fibre in the diet.<br><br>Furthermore, secondary values are food intake biomarkers, which are also associated with the intake of red meat (e.g. trimethyllysin, carnosin, anserin).