Comparison of Benefit and Survival for Different Etiologies of Adult Patients With Hydrocephalus Between Programmable Cerebrospinal Fluid Ventricular Shunt and Non-programmable Cerebrospinal Fluid Ventricular Shunt
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 325
- 主要终点
- Initial Shunt revision rate
研究概览
简要总结
Programmable valve (PV) has been shown as a solution to the high revision rate in pediatric hydrocephalus patients, but it remains controversial among adults. This study is to compare the overall revision rate, revision cause, and revision-free survival between PV and non-programmable valve (NPV) in adult patients with different hydrocephalus etiologies.
详细描述
Relatively high revision rates up to 32% of CSF shunting operations remained an unsolved problem for neurosurgeons. The cause of revisions were diverse, including overdrainage/underdrainage, shunting system obstruction, infection or technical skill related. Programmable valve (PV) has been shown as a solution to the high revision rate in pediatric hydrocephalus patients, but it remains controversial among adults. This study is to compare the overall revision rate, revision cause, and revision-free survival between PV and non-programmable valve (NPV) in adult patients with different hydrocephalus etiologies.
The investigators reviewed the chart of all patients with hydrocephalus receiving index ventricular CSF shunt operations conducted at a single institution in northern Taiwan from January 2017 to December 2017. Patients included in the study were followed up for at least five years. Statistical tests including independent t-test, Chi-square test and Fisher's exact test were used for comparative analysis, and Kaplan-Meier curve using log-rank test was performed to compare the revision-free survival between the PV and NPV groups
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •received shunting operations at Chang Gung Medical Foundation, Linkou Branch from 2017/01/01~2017/12/31
排除标准
- •Patients who received index ventricular CSF shunt at other hospitals,
- •Patients who received index ventricular CSF shunt before January 1st 2017,
- •Patients who were younger than 18
结局指标
主要结局
Initial Shunt revision rate
时间窗: since the time of index operation until the initial revision or 2022/07/31
the ratio of the total number of patients with at least one revision to the total number of patients included in this study
Revision-free survival
时间窗: since the time of index operation until the initial revision or 2022/07/31
the interval between index operation and the initial revision
Total Shunt revision rate
时间窗: since the time of index operation until the initial revision or 2022/07/31
the ratio of the total number of revisions to the total number of ventricular CSF shunt operations
Type of the revision operation
时间窗: since the time of index operation until the initial revision or 2022/07/31
the detailed description of the revision operation
The cause of shunt revision
时间窗: since the time of index operation until the initial revision or 2022/07/31
the cause of the shunt malfunction warranting revision operation
次要结局
- Shunt revision-free survival among different hydrocephalus etiologies(since the time of index operation until the initial revision or 2022/07/31)
