Combined Electroencephalogram, Magnetic Resonance Imaging-Positron Emission Tomography of Dexmedetomidine Induced Sleep
Overview
- Phase
- Not Applicable
- Intervention
- dexmedetomidine
- Conditions
- Dexmedetomidine Induced Sedation
- Sponsor
- Massachusetts General Hospital
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Number of Participants With Changes in the Brains Default Mode Network.
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
The investigators are doing this research study to find out how and where dexmedetomidine, a sedative anesthetic, acts in the brain. The investigators will do this by using a machine that records the brains electrical activity, called an electroencephalogram (EEG), and brain imaging scans to look at the brain.
Investigators
Oluwaseun Johnson-Akeju, MD, MMSc
Assistant in Anesthaesia
Massachusetts General Hospital
Eligibility Criteria
Inclusion Criteria
- •American Society of Anesthesiologists (ASA) physical status I
- •18 to 35 years of age
Exclusion Criteria
- •MRI and/or PET screening criteria not met
- •Abnormal sleep habits/known or suspected sleep disorder(s)
- •Taking medication that alters sleep, cognitive function, or both -History of a known neurological or psychiatric problem -Younger than 18 or older than 35 years of age
Arms & Interventions
Active study arm
Subjects recruited into this study will be required to undergo two magnetic resonance imaging- positron emission tomography (MRI-PET) scans of the brain in addition to high density electroencephalogram (EEG) acquisition. The first scan will be a baseline scan while the second scan will be performed while dexmedetomidine is being infused.
Intervention: dexmedetomidine
Outcomes
Primary Outcomes
Number of Participants With Changes in the Brains Default Mode Network.
Time Frame: 1.5hrs
Number of participants with changes in the Default Mode network during loss and recovery of consciousness under dexmedetomidine induced sedation versus baseline as assessed by changes in blood oxygen level depended (BOLD) signals during the awake, unconscious, and recovery states.