Transcranial Direct Current Stimulation (tDCS) as a Cognitive Functioning Enhancement Treatment for ADHD Patients Compared to Healthy Controls
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 63
- 试验地点
- 1
- 主要终点
- Navon task
研究概览
简要总结
This study will examine the possible effects of tDCS (Transcranial Direct Current Stimulation) treatment to the left DLPFC on cognitive functions which were found to be deficient amongst ADHD patients. The study will include 100 subjects, 50 of whom diagnosed with ADHD. Subjects will complete the ASRS questionnaire to measure ADHD symptoms severity. Next, subjects will complete a series of cognitive tasks, after which they will receive either tDCS treatment or a sham treatment. Finally, subjects will repeat the cognitive tasks. Later that day, a telephonic follow up will take place. ADHD symptoms will be assessed again the next day.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Participation criteria for healthy participants
- •Right hand dominance.
- •No psychiatric nor neural diagnosis.
- •Participants must be able to comprehend the study's procedure and sign an informed consent.
- •Participation criteria for ADHD diagnosed participants
- •ADHD diagnosis (according to DSM V).
- •Right hand dominance.
- •Participants must be able to comprehend the study's procedure and sign an informed consent.
- •Participants who regularly use Methylphenidate will be required to avoid the medication for 24 hours prior to study and 12 hours post study.
排除标准
- •a. Other psychiatric diagnoses (additional to ADHD). b. Drug use (excluding Methylphenidate). c. Neurological disorders. d. Pacemaker, Insulin pump
研究组 & 干预措施
Healthy control tDCS
干预措施: Transcranial Direct Current Stimulation (Device)
Healthy control Sham
干预措施: Sham (Device)
ADHD tDCS
干预措施: Transcranial Direct Current Stimulation (Device)
ADHD Sham
干预措施: Sham (Device)
结局指标
主要结局
Navon task
时间窗: through study completion, up to 1 hour after treatment
change in accuracy, shorter RT's
Stop-signal
时间窗: through study completion, up to 1 hour after treatment
change in response inhibition: shorter SSRT
N-back
时间窗: through study completion
change in working memory: increase in hit rate
Stroop
时间窗: through study completion, up to 1 hour after treatment
change in interference control: smaller interference effect
Time Reproduction task
时间窗: through study completion, up to 1 hour after treatment
change in time perception: increased accuracy
Continuous Performance Task
时间窗: through study completion, up to 1 hour after treatment
change in continuous concentration: increase in accuracy
次要结局
未报告次要终点
研究者
Noa Beiman
Principal Investigator
Hebrew University of Jerusalem