Effect of Granisetron on Usage of Sympathomimetics During Caesarean Section - a Retrospective Analysis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 240
- 试验地点
- 1
- 主要终点
- Sympathomimetics
研究概览
简要总结
The aim of the present study is to quantify the dose and usage of sympathomimetics used in caesarean section.
详细描述
Recent metaanalysis showed significantly reduced hypotension and bradycardia in patients undergoing caesarean section in spinal anesthesia when 5-hydroxytryptamine 3 receptor antagonists were used prophylactically.
Due to this fact in our clinic the standard procedure was changed. All patients for caesarean section receive Granisetron before spinal anesthesia.
The aim of the present study is to evaluate the usage and dose of sympathomimetics during spinal anesthesia.
Therefore the investigators will evaluate approximately 120 participants who received granisetron and 120 participants who did not receive 5-hydroxytryptamine 3 receptor antagonists.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •caesarean section in spinal anesthesia
排除标准
- •withdrawal
- •incomplete documentation
研究组 & 干预措施
No Granisetron
120 Patients prior to changes of intern standards of caesarean section. Before march 2017 no patient undergoing elective caesarean section received Granisetron as a matter of routine.
干预措施: No Granisetron (Drug)
With Granisetron
120 Patients after changes of intern standards of caesarean section. After march 2017 all patient undergoing elective caesarean section received Granisetron as a matter of routine.
干预措施: Granisetron Hydrochloride (Drug)
结局指标
主要结局
Sympathomimetics
时间窗: 30 minutes starting with induction of spinal anesthesia.
Type of sympathomimetics during during the operation
次要结局
- Volume substitution(30 minutes starting with induction of spinal anesthesia.)
- Haemotherapy(30 minutes starting with induction of spinal anesthesia.)
- Uterotonic agents(30 minutes starting with induction of spinal anesthesia.)
- Sympathomimetics(30 minutes starting with induction of spinal anesthesia.)
- Duration until first application of sympathomimetics(30 minutes starting with induction of spinal anesthesia.)
- Oxytocin(30 minutes starting with induction of spinal anesthesia.)
研究者
Dr. med. Florian Raimann
Dr. med. Florian Raimann
Johann Wolfgang Goethe University Hospital