Surgical Treatment of Marfan Syndrome With Subluxation Lens

Active, not recruiting

• Conditions: Lens Subluxation or Dislocation; Marfan Syndrome
• Interventions: Procedure: surgical treatment of Marfan Syndrome with subluxation lens

• Registration Number: NCT05578469
• Lead Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

Brief Summary

To analyze the postoperative visual effects, and to compare the safety and efficacy of different surgical treatment with of Marfan Syndrome with subluxation lens.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-01-01
• Status Verified: 2022-09
• Study First Submitted: 2022-10-11
• Study First Submitted QC: 2022-10-11
• Last Update Submitted: 2022-10-11
• Study First Posted: 2022-10-13
• Last Update Posted: 2022-10-13
• Primary Completion: 2022-11-01
• Study Completion: 2024-12-30

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

1. Patients diagnosed with MFS according to the revised Ghent etiology.
2. refractive errors difficult to correct.
3. pupillary block glaucoma caused by severe dislocation of the lens

Exclusion Criteria

Keratoconus, late glaucoma, uveitis, history of traumatic lens dislocation, and preoperative retinal rupture with or without retinal detachment (RD)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
posterior chamber intraocular lens(IOL) implantation with a Cionni capsular tension ring (CTR)	surgical treatment of Marfan Syndrome with subluxation lens	-
sutured scleral fixation of posterior chamber IOL/ posterior chamber IOL and CTR	surgical treatment of Marfan Syndrome with subluxation lens	-

Primary Outcome Measures

Name	Time	Method
postoperative complication	Early and late stages
intraocular pressure	3 month postoperatively
Uncorrected distance visual acuity	3 month postoperatively
Corrected distance visual acuity	3 month postoperatively

Secondary Outcome Measures

Name	Time	Method
Postoperative astigmatism and astigmatism axial of cornea	3 month postoperatively
endothelial cell count	3 month postoperatively

Trial Locations

Locations (1)

Second Affiliated Hospital, Zhejiang University School of Medicine; 🇨🇳 Hangzhou, China