Quality of Pediatric Resuscitation in a Multicenter Collaborative
- Conditions
- Cardiac ArrestCardiopulmonary Arrest
- Registration Number
- NCT02708134
- Lead Sponsor
- Children's Hospital of Philadelphia
- Brief Summary
This is a prospective, observational, multi-center cohort study of pediatric cardiac arrests.
The purpose of the study is to determine the association between chest compression mechanics (rate, depth, flow fraction, compression release) and patient outcomes. In addition, the investigators will determine the association of post cardiac arrest care with patient outcomes.
- Detailed Description
Cardiac arrests in children are a major public health problem. Thousands of children each year in the USA are treated with cardiopulmonary resuscitation (CPR) and managed after their cardiac arrest. Neurological outcomes following these in-hospital CPR events are often abnormal. As children with neurological deficits following CPR are a major burden for families and society, improving neurological outcomes through superior chest compression delivery during CPR and optimal care and management after cardiac arrest is an important clinical goal.
Therefore, the objective of this investigation is to obtain evidentiary support to associate the relationship of quantitative CPR quality data (depth, rate, chest compressions (CC) fraction, compression release) during CPR, post-cardiac arrest care (PCAC) and patient survival in those children who suffer an arrest within the study (RES-Q) Network.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 5000
- Patient received chest compressions for at least 1 minute
- Patient between gestational age ≥37 weeks and 17 years of age
- Patient had a quality of CPR measurements device (eg., Zoll Medical chest compression sensor) in place during chest compressions
- Patient on extracorporeal membrane oxygenation (ECMO) therapy at beginning of CPR event
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Aggregate score composed of American Heart Association (AHA) recommended depth, rate, and chest compression fraction during CPR 10 Years Primary outcome: "Guideline-compliant CPR" which will be determined by an aggregate score comprised of the following three components: depth, rate, and chest compression fraction. The three components will be analyzed in 30 and 60 second epochs. "Guideline-compliant CPR" requires that each component meet the following criteria: 1) Age-determined American Heart Association (AHA) guideline recommended depth; 2) rate ≥ 90 and ≤ 120 CC/min; and 3) CC Fraction ≥ 0.80. Depth, rate, and CC Fraction will be calculated for each epoch and an aggregate score will be assigned. The primary analysis will be performed on that total score.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (47)
Nemour's Children's Hopistal
🇺🇸Wilmington, Delaware, United States
Upstate Golisano Children's Hospital
🇺🇸Syracuse, New York, United States
Kentucky Children's Hospital
🇺🇸Lexington, Kentucky, United States
All Children's Hospital
🇺🇸Saint Petersburg, Florida, United States
Chldren's Hospital of Orange County
🇺🇸Orange, California, United States
Mount Sinai Kravis Children's Hospital
🇺🇸New York, New York, United States
Albany Medical Center
🇺🇸Albany, New York, United States
Akron Children's
🇺🇸Akron, Ohio, United States
Stollery Children's Hospital
🇨🇦Edmonton, Alberta, Canada
Great Ormond Street Hospital
🇬🇧London, United Kingdom
Alberta Children's
🇨🇦Calgary, Canada
Cohen Children's Medical Center
🇺🇸Queens, New York, United States
Cedars-Sinai Medical Center
🇺🇸Los Angeles, California, United States
Comer Children's Hospital
🇺🇸Chicago, Illinois, United States
University of Chicago, Comer Children's Hospital
🇺🇸Chicago, Illinois, United States
Medical City Children's Hospital
🇺🇸Dallas, Texas, United States
Seattle Children's Hospital
🇺🇸Seattle, Washington, United States
Massachusetts General Hospital
🇺🇸Boston, Massachusetts, United States
Boston Children's
🇺🇸Boston, Massachusetts, United States
Kaiser Permanente
🇺🇸Los Angeles, California, United States
Stanford University
🇺🇸Palo Alto, California, United States
Children's Healthcare of Atlanta (CHOA)
🇺🇸Atlanta, Georgia, United States
University of Iowa Stead Family Children's Hospital
🇺🇸Iowa City, Iowa, United States
Dartmouth Hitchcock Medical Center
🇺🇸Lebanon, New Hampshire, United States
Morgan Stanley Children's Hospital
🇺🇸New York, New York, United States
St. Louis Children's Hospital
🇺🇸Saint Louis, Missouri, United States
Nationwide Children's Hospital
🇺🇸Columbus, Ohio, United States
Children's Hospital of Philadelphia
🇺🇸Philadelphia, Pennsylvania, United States
University of Texas Southwestern
🇺🇸Dallas, Texas, United States
The Children's Hospital at Westmead
🇦🇺Westmead, New South Wales, Australia
Tokyo Metropolitan Children's Medical Center
🇯🇵Tokyo, Japan
The Johns Hopkins Hospital
🇺🇸Baltimore, Maryland, United States
Instituto Roosevelt
🇨🇴Bogotá, Colombia
Rady Children's Hospital
🇺🇸San Diego, California, United States
Children's Colorado
🇺🇸Aurora, Colorado, United States
Riley Hospital for Children
🇺🇸Indianapolis, Indiana, United States
Nebraska Medical Center
🇺🇸Omaha, Nebraska, United States
Cincinnati Children's Hospital Medical Center
🇺🇸Cincinnati, Ohio, United States
Medical College of Wisconsin
🇺🇸Milwaukee, Wisconsin, United States
BC Children's
🇨🇦Vancouver, British Columbia, Canada
KK Women's & Children's Hospital
🇸🇬Singapore, Singapore
National Taiwan University Hospital
🇨🇳Taipei, Taiwan
National University Hospital
🇸🇬Singapore, Singapore
University of North Carolina
🇺🇸Chapel Hill, North Carolina, United States
Medical University of South Carolina
🇺🇸Charleston, South Carolina, United States
Dell Children's Medical Center
🇺🇸Austin, Texas, United States
Children's Hospital of Richmond at VCU
🇺🇸Richmond, Virginia, United States