Monitoring of MDRO Dynamics and Resistance Mechanisms in a University Hospital Network
- Conditions
- MDRO
- Registration Number
- NCT04937361
- Lead Sponsor
- University of Luebeck
- Brief Summary
Survey on the prevalence of MDRO to monitor the import of MDRO from the community. Rectal swabs will be taken and cultivated. Survey on community-onset and nosocomial bloodstream infections will be documented and strains will be isolated. For each BSI a clinical data set will be obtained (e.g. patient age, gender, date of hospitalization, antibiotic therapy). Genetic analysis of MDRO from the prevalence and BSI study. In a subset of patients the microbiome-resistome interactome will be analysed in more detail. Furthermore, the impact of infection control measures due to the Covid-19 pandemic on nosocomial BSI will be investigated.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 12000
- at least 18 years old
- informed consent
- inpatient
- less than 18 years old
- Not capable of giving informed consent
- outpatient
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method monitoring of MDRO prevalence at hospital admission obtain a better understanding for the emergence of resistance within the microenvironment under selective pressure
integrate novel techniques for microbiome-resistome interaction analysis through study completion, after 4 years obtain a better understanding for the emergence of resistance within the microenvironment under selective pressure
monitoring of blood stream infections during hospitalization, up to 4 weeks obtain a better understanding for the emergence of resistance within the microenvironment under selective pressure
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Klinik für Infektiologie und Mikrobiologie
🇩🇪Lübeck, Germany