ATP Level and Cough Sensitivity to ATP in Subjects With Refractory/Unexplained Chronic Cough

Completed

• Conditions: Refractory/Unexplained Chronic Cough

• Registration Number: NCT05265871
• Lead Sponsor: Kefang Lai

Brief Summary

This is a cross-sectional study to investigate ATP level in induced sputum and cough sensitivity to ATP in subjects with refractory/unexplained chronic cough. 60 patients with refractory/unexplained chronic cough and 30 matched healthy controls were recruited. Demographic data, clinical characteristic, cough sacles and medical history records were collected. Cough chanllage(ATP and capsaicin) and ATP measurement in sputum were conducted.The difference of sputum ATP level between patients and control and the correlation between sputum ATP level and cough sensitivity to ATP were analyzed.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-02-23
• Study First Submitted QC: 2022-02-23
• Study First Posted: 2022-03-04
• Study Start: 2022-05-16
• Primary Completion: 2024-01-24
• Study Completion: 2024-01-24
• Status Verified: 2025-04
• Results First Submitted: 2025-04-03
• Results First Submitted QC: 2025-04-25
• Last Update Submitted: 2025-04-25
• Results First Posted: 2025-05-11
• Last Update Posted: 2025-05-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 131

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
ATP Level in Sputum Supernatant	ATP concentrations were measured in all specimens on the day of the last participant's enrollment.	ATP level in induced sputum in patients with refractory/unexplained chronic cough and healthy control

Secondary Outcome Measures

Name	Time	Method
ATP Cough Sensitivity	Each subject underwent ATP cough challenge on the day of enrollment.	Cough sensitivity for ATP in patients with refractory/unexplained chronic cough and healthy control. Lowest concentration of ATP that provoked at least 5 coughs (C5) is used to indicate cough sensitivity.

Trial Locations

Locations (1)

Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, The First Affiliated Hospital of Guangzhou Medical University; 🇨🇳 Guangzhou, Guangdong, China