A randomized controlled trial for 'tonifying kidney and removing blood stasis' traditional Chinese medicine in the treatment of patients with decreased ovarian reserve after chocolate cyst removal

Department of gynecology, Fangcun Branch of Guangdong Provincial Hospital of Traditional Chinese Medicine0 个研究点开始时间: 待定最近更新: 2023年2月20日

试验速览

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•(1) aged 18-39 years;
•(2) iatrogenic ovarian reserve function decreased after the operation of ovarian endometriosis (removal of cysts, unilateral adnexectomy, and intervention);
•(3) decreased ovarian reserve function: AMH was lower than the lower limit of the reference range of this age group (referring to the AMH test of patients, the standard of our hospital was: 20-24 years old: 1.52ng/ml, 25-29 years old: 1.2ng/ml, 30-34 years old: 0.711ng/ml, 36-39 years old: 0.405ng/ml);The follicular count of basal sinus was less than 5 at the 2nd to 5th day of menstruation. The basic FSH value on the 2-5 days of menstruation was greater than 10IU/L. The basic E2 value on the 2-5 days of menstruation was greater than 80pg/ml. Any one of the above four indicators can be included;
•(4) normal menstruation before operation.Show menstruation is normal or abnormal, but menstruation closes time 3 months less than;
•(5) TCM syndrome differentiation belongs to kidney deficiency and blood stasis;
•(6) informed consent.

•(1) use hormones at present or within 3 months before enrollment;
•(2) irregular menstruation before operation. Menstrual arrested over 3 months;
•(3) congenital gonadal hypoplasia; With a history of autoimmune diseases, pelvic infectious diseases, mumps, etc.;
•(4) polycystic ovary syndrome, hyperprolactinemia, dysfunctional uterine bleeding, hypogonadotropin, hypothyroidism and other endocrine diseases (disorders);
•(5) surgery history for other adnexas;
•(6) With a history of using reproductive toxic drugs, chemotherapy drugs and radiotherapy;
•(7) suspected genetic factors of ovarian decline;
•(8) pregnant or lactating women;
•(9) people with bad living habits (such as frequent smoking, excessive drinking, frequent hair coloring, excessive weight loss, etc.);
•(10) patients with severe mental illness;
•(11) participated in other clinical trials in the past 3 months;
•(12) bilateral adnexectomy due to Chocolate cyst; Chocolate cyst recurrence.

发起方

Department of gynecology, Fangcun Branch of Guangdong Provincial Hospital of Traditional Chinese Medicine