The effects of hormonal contraception on the HPA-axis functioning

• Conditions: gezonde vrouwen met hormonale anticonceptiegebruik; birth control pill; stress system

• Registration Number: NL-OMON38821
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

Healthy female participants using either a hormonal contraceptive combined method (Microgynon30, Stediril30, Marvelon) or a progesterone-only method (Mirena)

Exclusion Criteria

Female subjects with a history of psychiatric illness and/or psychotherapeutic treatments; drug abuse; neurological, cardiovascular or respiratory diseases, allergies, asthma; pregnancy or lactation.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Serum levels of estradiol, progesterone, cortisol, FSH and LH at baseline and<br /><br>in response to the Synacthen test.<br /><br>Basal serum cortisol binding globulin (CBG) and ACTH levels.<br /><br>DNA for genotyping functional SNPs. Genotyping will be performed in<br /><br>glucocorticoid receptor (GR) in order to control for genetic changes.<br /><br>Saliva levels of free cortisol at baseline and in response to the Synacthen<br /><br>test.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Basal cortisol levels as measured in hair strands; Heart rate measurements</p><br>