Explore the Causes and Predictors of Early Neurological Deterioration Occurred in Patients With Acute Ischemic Stroke
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Cerebral Infarction
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
- Enrollment
- 1200
- Locations
- 1
- Primary Endpoint
- National Institutes of Health Stroke Scale
- Last Updated
- 7 years ago
Overview
Brief Summary
This study set out to explore the risk factors of early neurological deterioration (END) occurred in patients with acute ischemic stroke and to investigate the corresponding predictors.
Detailed Description
END refers to the illness aggravation occurred in the early stage of stroke and often indicates a poor outcome. Some clinical scales may play an important role in its diagnoses and treatments. Across the reviewed studies, the risk factors of END, which included biochemical parameters, neuroimaging, ect. were explored incompletely and the effective predictors of END is unknown. We aimed to explore the risk factors of END and investigate the predictive value of certain scales.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Subjects with acute ischemic stroke
- •Subjects with detailed progress notes
Exclusion Criteria
- •Subjects with thrombolysis therapy
- •Subjects with transient ischemia attach
- •Subjects complicated with seriously underlying diseases
Outcomes
Primary Outcomes
National Institutes of Health Stroke Scale
Time Frame: 7 days
National Institutes of Health Stroke Scale (NIHSS) can assess the severity of stroke. The total score of NIHSS ranges from 0 to 42, with higher scores indicating better neurological function.
Canadian Neurological Scale
Time Frame: 7 days
Canadian Neurological Scale (CNS) can assess the severity of stroke as well. The total score of CNS ranges from 0 to 10, with higher scores indicating worse neurological function.
Secondary Outcomes
- Neuroimaging data(7days)
- Blood parameters(7days)