Genetic Studies of Early-onset Dementia
Overview
- Phase
- N/A
- Intervention
- Medical questionnaire
- Conditions
- Dementia, Early Onset
- Sponsor
- Columbia University
- Enrollment
- 1000
- Locations
- 2
- Primary Endpoint
- Genetic risk variants associated with early-onset dementia
- Status
- Recruiting
- Last Updated
- 3 days ago
Overview
Brief Summary
The aim of this study is to identify genetic factors that contribute to risk and progression of early-onset dementia (loss of memory function before the age of 70 years) across all ethnic groups, including Alzheimer's Disease, mild cognitive impairment and other dementias.
Detailed Description
The study population includes individuals with Alzheimer's disease, mild cognitive impairment, other forms of dementia, as well as cognitively healthy individuals with a family history of dementia. Participants include males and females across all racial and ethnic groups.
Investigators
Christiane Reitz, MD, PhD
Associate Professor of Neurology and Epidemiology
Columbia University
Eligibility Criteria
Inclusion Criteria
- •35 years and older
- •Individuals experiencing memory concerns or diagnosed with dementia and their family members that are unrelated healthy controls without dementia.
Exclusion Criteria
- •\- Individuals with competing diagnosis such as Huntington's disease, traumatic brain injury, drug or alcohol abuse, or schizophrenia, etc., unless family members of a dementia affected individual
Arms & Interventions
Dementia/Alzheimer's Disease
Individuals with Alzheimer's Disease or other dementia that began before age 70
Intervention: Medical questionnaire
Cognitively Healthy
Cognitively healthy individuals over the age of 35 years with a family history of dementia.
Intervention: Blood draw
Cognitively Healthy
Cognitively healthy individuals over the age of 35 years with a family history of dementia.
Intervention: Neurocognitive testing
Cognitively Healthy
Cognitively healthy individuals over the age of 35 years with a family history of dementia.
Intervention: Medical questionnaire
Mild Cognitive Impairment
Individuals with mild cognitive impairment that began before age 70
Intervention: Medical questionnaire
Dementia/Alzheimer's Disease
Individuals with Alzheimer's Disease or other dementia that began before age 70
Intervention: Blood draw
Dementia/Alzheimer's Disease
Individuals with Alzheimer's Disease or other dementia that began before age 70
Intervention: Neurocognitive testing
Mild Cognitive Impairment
Individuals with mild cognitive impairment that began before age 70
Intervention: Blood draw
Mild Cognitive Impairment
Individuals with mild cognitive impairment that began before age 70
Intervention: Neurocognitive testing
Early-onset dementia prior to the age of 65.
Individuals diagnosed with early-onset dementia prior to the age of 65.
Intervention: Blood draw
Early-onset dementia prior to the age of 65.
Individuals diagnosed with early-onset dementia prior to the age of 65.
Intervention: Neurocognitive testing
Early-onset dementia prior to the age of 65.
Individuals diagnosed with early-onset dementia prior to the age of 65.
Intervention: Medical questionnaire
Outcomes
Primary Outcomes
Genetic risk variants associated with early-onset dementia
Time Frame: 2 years
Genetic factors will be measured through genome-wide genotyping arrays and/or whole-genome sequencing, and then correlated with Alzheimer disease and related phenotypes, such as cognitive impairment, functional impairment, and relevant biomarkers.
Changes in blood biomarkers in early-onset dementia
Time Frame: 2 years
Blood biomarkers including plasma amyloid beta and tau protein will be assessed in blood and correlated with onset and progression of memory loss and functional impairment