Genetic Studies of Early-onset Dementia
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- Genetic risk variants associated with early-onset dementia
研究概览
简要总结
The aim of this study is to identify genetic factors that contribute to risk and progression of early-onset dementia (loss of memory function before the age of 70 years) across all ethnic groups, including Alzheimer's Disease, mild cognitive impairment and other dementias.
详细描述
The study population includes individuals with Alzheimer's disease, mild cognitive impairment, other forms of dementia, as well as cognitively healthy individuals with a family history of dementia. Participants include males and females across all racial and ethnic groups.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 35 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •35 years and older
- •Individuals experiencing memory concerns or diagnosed with dementia and their family members that are unrelated healthy controls without dementia.
排除标准
- •- Individuals with competing diagnosis such as Huntington's disease, traumatic brain injury, drug or alcohol abuse, or schizophrenia, etc., unless family members of a dementia affected individual
研究组 & 干预措施
Dementia/Alzheimer's Disease
Individuals with Alzheimer's Disease or other dementia that began before age 70
干预措施: Medical questionnaire (Other)
Cognitively Healthy
Cognitively healthy individuals over the age of 35 years with a family history of dementia.
干预措施: Blood draw (Genetic)
Cognitively Healthy
Cognitively healthy individuals over the age of 35 years with a family history of dementia.
干预措施: Neurocognitive testing (Other)
Cognitively Healthy
Cognitively healthy individuals over the age of 35 years with a family history of dementia.
干预措施: Medical questionnaire (Other)
Mild Cognitive Impairment
Individuals with mild cognitive impairment that began before age 70
干预措施: Medical questionnaire (Other)
Dementia/Alzheimer's Disease
Individuals with Alzheimer's Disease or other dementia that began before age 70
干预措施: Blood draw (Genetic)
Dementia/Alzheimer's Disease
Individuals with Alzheimer's Disease or other dementia that began before age 70
干预措施: Neurocognitive testing (Other)
Mild Cognitive Impairment
Individuals with mild cognitive impairment that began before age 70
干预措施: Blood draw (Genetic)
Mild Cognitive Impairment
Individuals with mild cognitive impairment that began before age 70
干预措施: Neurocognitive testing (Other)
Early-onset dementia prior to the age of 65.
Individuals diagnosed with early-onset dementia prior to the age of 65.
干预措施: Blood draw (Genetic)
Early-onset dementia prior to the age of 65.
Individuals diagnosed with early-onset dementia prior to the age of 65.
干预措施: Neurocognitive testing (Other)
Early-onset dementia prior to the age of 65.
Individuals diagnosed with early-onset dementia prior to the age of 65.
干预措施: Medical questionnaire (Other)
结局指标
主要结局
Genetic risk variants associated with early-onset dementia
时间窗: 2 years
Genetic factors will be measured through genome-wide genotyping arrays and/or whole-genome sequencing, and then correlated with Alzheimer disease and related phenotypes, such as cognitive impairment, functional impairment, and relevant biomarkers.
Changes in blood biomarkers in early-onset dementia
时间窗: 2 years
Blood biomarkers including plasma amyloid beta and tau protein will be assessed in blood and correlated with onset and progression of memory loss and functional impairment
次要结局
未报告次要终点
研究者
Christiane Reitz, MD, PhD
Associate Professor of Neurology and Epidemiology
Columbia University