临床试验/NCT04680013

NCT04680013已完成不适用

Genetic Studies in Familial Dementia

University of Miami1 个研究点分布在 1 个国家目标入组 4,884 人开始时间: 2007年6月1日最近更新: 2025年3月3日

适应症

试验速览

阶段: 不适用
状态: 已完成
发起方: University of Miami
入组人数: 4,884
试验地点: 1
主要终点: Correlation between genetic factors and Alzheimer disease, dementia, and related phenotypes.

研究概览入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

The purpose of this study is to identify genetic factors that contribute to or cause dementia (loss of memory) and related disorders across all ages and ethnic groups. This includes a number of neurological diseases such as early and late-onset Alzheimer disease, mild cognitive impairment, and other dementias.

研究设计

研究类型: Observational

入排标准

年龄范围: 18 Years 至 —（Adult, Older Adult）
性别: All
接受健康志愿者: 是

入选标准

•18 years and older
•Patients diagnosed with dementia, their family members and unrelated healthy controls without dementia.

排除标准

•Individuals with competing diagnosis such as: Amyotrophic lateral sclerosis, Frontotemporal lobar degeneration, Multiple system atrophy, Corticobasal degeneration, Progressive Supranuclear Palsy, Huntington's disease, traumatic brain injury, drug or alcohol abuse, or schizophrenia, etc. (unless family members of a dementia affected individual).

结局指标

主要结局

Correlation between genetic factors and Alzheimer disease, dementia, and related phenotypes.

时间窗: 5 years

Genetic factors will be measured through genome-wide genotyping arrays and/or whole-genome sequencing, and then correlated with Alzheimer disease and related phenotypes, such as cognitive impairment, functional impairment, and relevant biomarkers. .

次要结局

未报告次要终点

研究者

发起方

University of Miami

申办方类型

Other

责任方

Principal Investigator

主要研究者

Margaret Pericak-Vance

Professor

University of Miami

研究点 (1)

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