Genetic Studies in Familial Dementia

University of Miami1 site in 1 country4,884 target enrollmentJune 1, 2007

ConditionsDementia of Alzheimer Type Alzheimer Disease, Late Onset Alzheimer Disease, Early Onset Mild Cognitive Impairment Dementia

Overview

Phase: N/A
Intervention: Not specified
Conditions: Dementia of Alzheimer Type
Sponsor: University of Miami
Enrollment: 4884
Locations: 1
Primary Endpoint: Correlation between genetic factors and Alzheimer disease, dementia, and related phenotypes.
Status: Completed
Last Updated: last year

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The purpose of this study is to identify genetic factors that contribute to or cause dementia (loss of memory) and related disorders across all ages and ethnic groups. This includes a number of neurological diseases such as early and late-onset Alzheimer disease, mild cognitive impairment, and other dementias.

Registry

clinicaltrials.gov

Start Date

June 1, 2007

End Date

October 29, 2024

Last Updated

last year

Study Type

Observational

Sex

All

Investigators

Sponsor

University of Miami

Responsible Party

Principal Investigator

Margaret Pericak-Vance

Professor

University of Miami

Eligibility Criteria

Inclusion Criteria

•18 years and older
•Patients diagnosed with dementia, their family members and unrelated healthy controls without dementia.

Exclusion Criteria

•Individuals with competing diagnosis such as: Amyotrophic lateral sclerosis, Frontotemporal lobar degeneration, Multiple system atrophy, Corticobasal degeneration, Progressive Supranuclear Palsy, Huntington's disease, traumatic brain injury, drug or alcohol abuse, or schizophrenia, etc. (unless family members of a dementia affected individual).

Outcomes

Primary Outcomes

Correlation between genetic factors and Alzheimer disease, dementia, and related phenotypes.

Time Frame: 5 years

Genetic factors will be measured through genome-wide genotyping arrays and/or whole-genome sequencing, and then correlated with Alzheimer disease and related phenotypes, such as cognitive impairment, functional impairment, and relevant biomarkers. .