Genetic Studies in Familial Dementia

Completed

• Conditions: Alzheimer Disease, Early Onset; Dementia of Alzheimer Type; Alzheimer Disease, Late Onset; Mild Cognitive Impairment; Dementia

• Registration Number: NCT04680013
• Lead Sponsor: University of Miami

Brief Summary

The purpose of this study is to identify genetic factors that contribute to or cause dementia (loss of memory) and related disorders across all ages and ethnic groups. This includes a number of neurological diseases such as early and late-onset Alzheimer disease, mild cognitive impairment, and other dementias.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-06-01
• Study First Submitted: 2020-12-17
• Study First Submitted QC: 2020-12-17
• Study First Posted: 2020-12-22
• Primary Completion: 2024-10-29
• Study Completion: 2024-10-29
• Status Verified: 2025-02
• Last Update Submitted: 2025-02-26
• Last Update Posted: 2025-03-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 4884

Inclusion Criteria

1. 18 years and older
2. Patients diagnosed with dementia, their family members and unrelated healthy controls without dementia.

Exclusion Criteria

1. Individuals with competing diagnosis such as: Amyotrophic lateral sclerosis, Frontotemporal lobar degeneration, Multiple system atrophy, Corticobasal degeneration, Progressive Supranuclear Palsy, Huntington's disease, traumatic brain injury, drug or alcohol abuse, or schizophrenia, etc. (unless family members of a dementia affected individual).

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Correlation between genetic factors and Alzheimer disease, dementia, and related phenotypes.	5 years	Genetic factors will be measured through genome-wide genotyping arrays and/or whole-genome sequencing, and then correlated with Alzheimer disease and related phenotypes, such as cognitive impairment, functional impairment, and relevant biomarkers.; .

Trial Locations

Locations (1)

University of Miami; 🇺🇸 Miami, Florida, United States