Multimodal neuroimaging study of the suicidal ideation functional brain network regulated by soothing liver and regulating qi acupuncture on the suicidal ideation depressio

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: Not specified

Inclusion Criteria

1. Suicide ideation depression subjects:
(1)Right handed, han nationality, length of education = 6years
(2)Men or women aged 35-55 years;
(3)Meet the diagnostic criteria for DSM-V of depression;
(4)Hamilton Depression Scale -24 items(HAND-24)score=20;
(5)Beck Suicidal Ideation Scale rated as positive;
(6)Suicidal ideation only, no experience of self-injury or suicidal behaviour
(7)Those who voluntarily participate in the study, with written informed consent signed by the patient and family members, and accompanied by family members throughout the study period.
2. Healthy subjects:
(1)Right handed, han nationality, length of education = 6years;
(2)Men or women aged 35-55 years;
(3)No history of any neurological or psychiatric disorders and family history of genetic disorders, with a HAMD-17 score <7;
(4)No physical abnormalities during the trial period(e.g. flu, fever, etc.) ;
(5)No drugs or alcohol for at least 2 days prior to participation in the trial, and no stimulant drug use for at least 1 month;
(6)The subjects themselves signedthe informed consent.

Exclusion Criteria

1. Suicide ideation depression subjects:
(1)With bidirectional depression and other psychiatric disorders in the DSM-V diagnosis;
(2)A history of self-injurious or suicidal behaviour;
(3)Severe depression with unstable emotion and abnormal behaviour with difficulty in cooperating with the assessment;
(4)Serious primary diseases such as cardiovascular system, liver, kidney and hematopoietic system;
(5)Chronic pain(such as migraine, women with dysmenorrhea);
(6)Pregnancy, lactation, or plans to become pregnant within 1 year;
(7)Brain with definite organic lesions or severe asymmetry between the right and left side of the cranial structure..
(8)Nuclear magnetic contraindications (such as metal implant, vascular stents, cardiac pacemakers, false tooth, claustrophobia, etc.);
(9)Has received acupuncture treatment within 6 months;
(10)Has taken antidepressant or other psychotropic drugs within 6 months and with drug dependence;
(11)Transsexual, homosexuality, abnormal sexual orientation, special fetishes, alcohol addict, etc.
(12)Participation in a similar study in the last 3 months.
2. Healthy subjects:
(1)Serious primary diseases such as cardiovascular system, brain, liver, kidney, hematopoietic system, mental disease and obvious cognitive dysfunction;
(2)Chronic pain(such as migraine, women with dysmenorrhea);
(3)Women during pregnancy and lactation
(4)Brain with definite organic lesions or severe asymmetry between the right and left side of the cranial structure
(5)Nuclear magnetic contraindications (such as metal implant, vascular stents, cardiac pacemakers, false tooth, claustrophobia, etc.);
(6)Has received acupuncture treatment within 6 months;
(7)Transsexual, homosexuality, abnormal sexual orientation, special fetishes, alcohol or drug abuse, etc.

Study & Design

Study Type: Interventional study

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Multimodal image data;

Secondary Outcome Measures

Name	Time	Method
Clinical Global Impression;Hamilton Depression Scale -24 items;Self-rating Depression Scale;The World Health Organization Summary Quality of Life-BREF;Beck Suicidal Ideation Scale;