Comparison of Respiratory Variations of the Pulse Oximetry Plethysmographic Raw Signal and Pulse Pressure During Abdominal Surgery (PLETHYSMO)
试验速览
- 阶段
- 不适用
- 入组人数
- 20
- 主要终点
- ∆PP: pulse pressure variation
研究概览
简要总结
The waveform plethysmographic signal can be used to establish an index for predicting fluid responsiveness (∆POP: respiratory variation of the plethysmographic waveform of pulse oximetry). This index was validated in some studies and because of its non-invasiveness it seems very interesting in anesthesia.
However, in a previous study the investigators evaluated the correlation between the results provided by this index (∆POP) and those of the reference index (∆PP: pulse pressure variation), and the obtained results were significantly lower than what had been previously described. In this study, the index was calculated from a recording of a filtered signal. This unavoidable application of a filter on anesthesia monitors could contribute to the discrepancy between the ∆POP and the ∆PP.
The realization of a new study, comparing ∆PP and ∆POP obtained from an unfiltered plethysmographic signal, should answer the ∆POP ability to be used in place of ∆PP.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Hospital patient in general surgery and digestive department
- •Digestive sus mesocolic surgery with direct abdominal approach justifying a semi-invasive hemodynamic monitoring by arterial catheterization (liver, pancreatic, gastric and duodenal surgery)
- •Surgical approach by laparotomy
- •Patient under general anesthesia with mechanical ventilation
- •Agreeing to participate in the study after receiving information note
排除标准
- •Known left systolic ventricular and/or diastolic failure
- •Arrhythmias
- •Surgery performed with thoracic approach
- •Surgery by laparoscopy
- •Emergency surgery
- •Hypersensitivity or allergic to any of the product used for usual anesthesia, hypersensitivity to soya or egg lecithin
- •Personal or familial history of malignant hyperthermia
- •Severe kidney impairment (creatinin clearance <30ml/min)
- •Patients who participated in the previous month to another study protocol
- •Pregnant women or nursing
- •Under-age
结局指标
主要结局
∆PP: pulse pressure variation
时间窗: Day 0
reference index measured during abdominal surgery
∆POP: respiratory variation of the plethysmographic waveform of pulse oximetry
时间窗: Day 0
noninvasive index obtained from plethysmographic raw signal measured during abdominal surgery
次要结局
未报告次要终点