Respiratory Variability in Aortic Blood Velocity Measured by Suprasternal View as an Indicator of Fluid Responsiveness

Not Applicable

Completed

• Conditions: Cardiovascular System
• Interventions: Device: Fluid challenge with 250 ml of Ringer Lactate

• Registration Number: NCT02791984
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

Respiratory changes in aortic blood velocity have been described as an indicator of fluid responsiveness when measured in the left ventricular outflow tract by trans esophageal echography. A threshold value of 12% allowed discrimination between responders and nonresponders with a sensitivity of 100% and a specificity of 89%. The suprasternal window is already used to measure cardiac output. The primary endpoint of this study is to determine the predictive value of the respiratory variability in aortic blood velocity measured by suprasternal view (∆VpicSS) as an indicator of fluid responsiveness. The secondary endpoint is to compare maximum velocity and velocity time integral measured by suprasternal and transthoracic view.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2015-04
• Primary Completion: 2016-03
• Study Completion: 2016-03
• Status Verified: 2016-05
• Study First Submitted: 2016-05-27
• Study First Submitted QC: 2016-06-01
• Last Update Submitted: 2016-06-01
• Study First Posted: 2016-06-07
• Last Update Posted: 2016-06-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 62

Inclusion Criteria

• Age more than 18 years
• American Society of Anesthesiologists (ASA) score 1 or 2
• General Anesthesia with mechanical ventilation
• General Surgery

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Exclusion Criteria

• Arrhythmia
• Spontaneous breathing activity
• Significant valvular disease

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Fluid challenge with 250 ml of Ringer Lactate	Fluid challenge with 250 ml of Ringer Lactate	-

Primary Outcome Measures

Name	Time	Method
Percentage of cardiac flow variability	At day 1(before surgery)	Percentage of cardiac flow variability between the 2 echographic measures. Echographic measures will be realized a first time before fluid challenge by suprasternal view and a second time after the fluid challenge by suprasternal view.

Secondary Outcome Measures

Name	Time	Method
Comparison of percentage of cardiac flow variability between transthoracic and suprasternal views	At day 1(before surgery)	Echographic measures will be realized a first time before fluid challenge by transthoracic and by suprasternal view and a second time after the fluid challenge by transthoracic and by suprasternal view.

Trial Locations

Locations (1)

Hopital de la Croix-Rousse, Hospices Civils de Lyon; 🇫🇷 Lyon, France