The state of the nervous system, psychology and eyes of HIV-infected children in comparison to healthy children.
Recruiting
- Conditions
- HIV, neuropathology, AIDS, children, co-morbidities of antiretroviral therapy
- Registration Number
- NL-OMON20039
- Lead Sponsor
- niversity of Amsterdam
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 80
Inclusion Criteria
Confirmed HIV-1 infection (cases only)
8-18 years of age
Exclusion Criteria
Trauma >30 minutes
Intracranial malignancy
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method europsychological performance<br /><br>MRI/MRS- white matter abnormalities, cerebral perfusion, metabolite concentrations<br /><br>Ophthalmological assessment outcomes<br /><br>Optical Coherence Tomography outcomes<br />
- Secondary Outcome Measures
Name Time Method Cerebrospinal fluid/blood: neuro-damage markers, immune activation markers<br /><br>Antiretroviral therapy concentration in CSF/Blood<br />