eurological, visual and neurocognitive performance in pediatric HIV-1- infected patients as compared to healthy controls.

Completed

• Conditions: brain disease; neurologic and neuropsychologic impairment; 10021460; 10047438; 10007951

• Registration Number: NL-OMON37553
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 80

Inclusion Criteria

Cases: Perinatally infected with HIV
Cases/controls: 8-17 years of age

Exclusion Criteria

Intracranial malignancy, history of traumatic brain injury with loss of consciousness > 30 minutes
Severe psychiatric disorders
MRI contra-indications (e.g. implanted active devices such as pacemakers or medication pumps, or metal splinters in eye, brain or lungs, claustrophobia)

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Main endpoints are diminished neurocognitive performance, deviations in<br /><br>neuroimaging parameters and ophthalmological measurements, comparing HIV<br /><br>positive cases to healthy controls. Several CSF and blood parameters will be<br /><br>measured and correlated to the results of the above mentioned tests.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>nvt</p><br>