Clinical and Radiographic Evaluation of Advanced Platelet Rich Fibrin Combined With Nano-crystalline Hydroxyapatite Bone Substitute for Management of Mandibular Molar Grade II Furcation Defects
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 28
- 主要终点
- Relative Vertical Clinical Attachment Level (RVCAL)
研究概览
简要总结
this study is to evaluate the use of advanced platelet rich fibrin (A-PRF) + nano-crystalline hydroxyapatite bone substitute combined with open flap debridement (OPD) versus open flap debridement alone in the management of mandibular molar grade II defects.
In the management of mandibular molar grade II furcation defects, no difference exists in gain of horizontal clinical attachment level between the use of advanced platelet rich fibrin (A-PRF) + with nano-crystalline hydroxyapatite bone substitute combined with open flap debridement (OPD) and open flap debridement (OPD) alone .
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patient-related criteria:
- •Systemically healthy patients.
- •Compliance with oral hygiene instructions and the maintenance program provided.
- •Accepts the 6 months follow-up period.
- •Provide informed consent.
- •Teeth related criteria:
- •Mature permanent tooth.
- •Asymptomatic mandibular molar with buccal Glickman class II furcation involvement.
- •Probing depth (PD) ≥ 5 mm and vertical PD ≥ 3 mm after Phase I therapy (scaling and root planing).
- •Presence of radiolucency in the furcation area on an intra-oral periapical radiograph
排除标准
- •Patient-related criteria:
- •Patients taking drugs known to interfere with periodontal wound healing in the last six months.
- •Pregnant or nursing women.
- •Uncooperative patients.
- •Teeth related criteria:
- •Teeth with interproximal supra-bony or intrabony defects.
- •Teeth with gingival recession.
- •Teeth with grade II or III mobility.
研究组 & 干预措施
Test Group
Advanced PRF (A-PRF) + nano-crystalline hydroxyapatite bone substitute combined with open flap debridement (OFD).
干预措施: Advanced PRF (A-PRF) + nano-crystalline hydroxyapatite bone substitute combined with open flap debridement (Procedure)
Control Group
Open flap debridement alone.
干预措施: Open flap debridement (Procedure)
结局指标
主要结局
Relative Vertical Clinical Attachment Level (RVCAL)
时间窗: 6 months
relative vertical clinical attachment level (RVCAL) along with gingival marginal level (GML) will be measured from the apical level of customized acrylic stents with grooves to ensure a reproducible placement of a periodontal probe
次要结局
- Relative Horizontal Clinical Attachment Level (PHCAL)(6 months)
- Probing Depth (PD)(6 months)
- Gingival margin Level (GML)(6 months)
研究者
Hadeer Ashraf Hassan Roushdy
Dentist
Cairo University