Intraarticular Xylitol Injections for Knee Osteoarthritis

Phase 4

• Conditions: Knee Osteoarthritis
• Interventions: Device: Xylitol

• Registration Number: NCT02104596
• Lead Sponsor: Hadassah Medical Organization

Brief Summary

Hypothesis: Intraarticular injections of isotonic Xylitol solution will improve pain in patients with knee osteoarthritis (OA).

Detailed Description

Not available

Study Timeline

• Status Verified: 2014-04
• Study First Submitted: 2014-04-02
• Study First Submitted QC: 2014-04-03
• Study First Posted: 2014-04-04
• Last Update Submitted: 2014-04-16
• Last Update Posted: 2014-04-17
• Study Start: 2014-05
• Primary Completion: 2016-04

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 96

Inclusion Criteria

• Age over 45
• Tibiofemoral osteoarthritis
• OA stage 2-3 on xray
• Pain VAS > 40mm
• No NSAIDs for 3 weeks
• No analgetics for 38 hours

Exclusion Criteria

• Pain VAS > 80mm
• Pain VAS in contralateral knee > 40mm
• Inflammatory arthritis
• Severe effusion
• Posttraumatic osteoarthritis
• Unstable knee
• Isolated patellofemoral disease
• Paracetamol hypersensitivity

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Xylitol injection	Xylitol	Intraarticular injection of Xylitol

Primary Outcome Measures

Name	Time	Method
Pain - visual analogue scale	3 months

Trial Locations

Locations (1)

Hadassah Medical Organization, Jerusalem, Israel; 🇮🇱 Jerusalem, Israel