Comparison of prevalence and clinical manifestation of thiamine deficiency status in patients with different in etiology

Phase 2

Completed

• Conditions: Cirrhotic patients thiamine deficiency; cirrhosis; Thiamine deficiency

• Registration Number: TCTR20211222006
• Lead Sponsor: Research Facilitation Division, Faculty of Medicine Vajira Hospital, Navamindradhiraj University

Brief Summary

121 eligible cirrhotic patients were enrolled. Alcoholic cirrhosis comprised 41/121 (33.88%). A comparison prevalence in alcoholic with non-alcoholic was 14.63% vs. 11.25% (P 0.59). Neither severity of disease nor baseline nutritional status was related to thiamine deficiency. HCC was the only factor related to thiamine deficiency. Almost thiamine deficiency status did not have either neurologic abnormality or any attention deficit.

Detailed Description

Not available

Study Timeline

• Study Completion: 2020-12-31
• Study Start: 2021-12-22
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 121

Inclusion Criteria

Cirrhotic patients were diagnosed by ultrasound, computer tomography scan (CT), transient elastography above 13 kPa, magnetic resonance imaging (MRI), or by liver biopsy

Exclusion Criteria

-who were diagnosed with thiamine deficiency or use of thiamine replacement therapy before enrolling
-acute illness in 2 weeks
-pregnant woman
-hyperthyroidism
-end-stage renal disease and on renal replacement therapy
-gastrointestinal tract surgery with anastomosis.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
prevalence of thiamine deficiency between alcoholic cirrhosis and non-alcoholic cirrhosis. at diagnosis prevalence

Secondary Outcome Measures

Name	Time	Method
factors influenced thiamine deficiency other than the etiology of cirrhosis at diagnosis data collection,clinical manifestation of thiamine deficiency patients in neurologic sign and symptom and attention deficit at diagnosis physical examination and ASRS test,improvement of thiamine deficiency after replacement 3 months 3 monts after thiamine replacement blood test and physical examination and ASRS test