A clinical trial to study a drug Dexmedetomedine for maintenance of vitals during surgeries and recovery profile after major surgeries under General anaesthesia.

Phase 4

• Conditions: Health Condition 1: K800- Calculus of gallbladder with acutecholecystitisHealth Condition 2: K319- Disease of stomach and duodenum, unspecifiedHealth Condition 3: C509- Malignant neoplasm of breast of unspecified siteHealth Condition 4: C189- Malignant neoplasm of colon, unspecified

• Registration Number: CTRI/2021/01/030676
• Lead Sponsor: Aarupadai Veedu medical college and hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 17 October 2022

Recruitment & Eligibility

• Status: Closed to Recruitment of Participants
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

ASA I and II

Patient posted for surgeries under GA lasting for more than 2 hours like modified radical mastectomy, radical neck dissection, resection anastomoses, staging laparotomy, etc.

Exclusion Criteria

Non consented patients

Pregnancy, obese, diabetic, chronic hypertensive, coronary artery disease, AV block

Preoperative hypotension/ bradycardia or dysrhythmia

Laparoscopic surgeries

Anticipated difficult intubation

Allergic to the drugs to be used

Patient on beta blockers or calcium channel blockers

ASA III and above

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Heart rate <br/ ><br>Mean arterial pressure <br/ ><br>Systolic BP <br/ ><br>Diastolic BPTimepoint: Before loading dose, <br/ ><br>Before premedication, <br/ ><br>Immediately after induction, <br/ ><br>Immediately after intubation, <br/ ><br>Every 10 mins after intubation till the end of the procedure, <br/ ><br>Immediately after extubation, <br/ ><br>Before shifting to PACU, <br/ ><br>Every 10mins for 1 hour in PACU, <br/ ><br>Every 15 mins till the first dose of rescue analgesia. <br/ ><br>

Secondary Outcome Measures

Name	Time	Method
Oxygen saturation <br/ ><br>Postoperative nausea and vomiting <br/ ><br>Time of recoveryTimepoint: Oxygen saturation for every 10 mins till the first hour in PACU, <br/ ><br>Post operative nausea and vomiting in the first 2 hours postoperative