Effect of Propofol on fentanyl-induced cough
Not Applicable
- Conditions
- fentanyl-induced cough.Complications of medical and surgical care,Opioids and related analgesics
- Registration Number
- IRCT201305216803N4
- Lead Sponsor
- Vice chancellor for research, Mazandaran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 240
Inclusion Criteria
Informed written consent; ASA class ?-??; Age between 18 - 50 years; Various elective surgical procedures under general anesthesia.
Exclusion criteria: History of asthma, chronic cough, lung disease; Smoking or substance abuse; Cardiac disease; Any disease or surgery of trachea or larynx; Upper respiratory tract infection in the previous four weeks; Impaired kidney or liver functions; Pregnancy and lactation; Medication with angiotensin-converting enzyme inhibitors (ACE), steroids, bronchodilators, antihistamine or antitussive drugs in the previous four weeks.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Cough. Timepoint: Within two minutes after fentanyl injection. Method of measurement: Record in Questionnaire.
- Secondary Outcome Measures
Name Time Method Systolic blood pressure. Timepoint: First and two minutes after fentanyl injection. Method of measurement: Noninvasive arterial blood pressure.;Diastolic blood pressure. Timepoint: First and two minutes after fentanyl injection. Method of measurement: Noninvasive arterial blood pressure.;Mean arterial blood pressure. Timepoint: First and two minutes after fentanyl injection. Method of measurement: Noninvasive arterial blood pressure.;Heart rate. Timepoint: First and two minutes after fentanyl injection. Method of measurement: electrocardiogram.;Oxygen saturation. Timepoint: First and two minutes after fentanyl injection. Method of measurement: Pulse oxymeter.