Combination of Hydroquinone and Fractional CO2 Laser vs. Hydroquinone Monotherapy in Melasma Treatment: A Randomized Split-face Clinical Trial
Phase 3
- Conditions
- melasma.Chloasma
- Registration Number
- IRCT20171222037987N1
- Lead Sponsor
- Esfahan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 40
Inclusion Criteria
Female patients
Age range of 20-50 years
Fitzpatrick skin types II-V
Bilateral melasma on cheeks
Exclusion Criteria
History of receiving laser therapy and topical therapeutic agents in the previous three months
History of receiving Isotretinoin in the past six months
History of receiving OCP, other bleaching creams, phenytoin, phototoxic and photoallergic drugs
Pregnancy
Lactating
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Severity of the melasma lesions was assessed objectively based on Darkness (D) and Homogeneity (H) using a 7-point scale (0-6). Timepoint: The darkness and homogeneity scores were obtained in the first visit and the 3 laser sessions at three-week intervals and the follow-up sessions at 1 and 3 months after the last laser session. Method of measurement: darkness and homogeneity : 7-point scale(compare with the sample) patient's satisfaction with the treatment :visual analogue scale (VAS) by scoring between 0 and 10 response to treatment : physician global assessment.
- Secondary Outcome Measures
Name Time Method Patient's satisfaction with the treatment. Timepoint: 3 months after the last laser session. Method of measurement: visual analogue scale (VAS) by scoring between 0 and 10.