Cardiometabolic Response to a Sodium-bicarbonated Mineral Water
Not Applicable
Completed
- Conditions
- Dyslipidemia
- Interventions
- Dietary Supplement: Mineral water
- Registration Number
- NCT02480816
- Lead Sponsor
- National Research Council, Spain
- Brief Summary
The effects of consuming a sodium-bicarbonated mineral water rich in bicarbonate, sodium, chloride, lithium and silicon are studied in humans. The aim of this assay was to determine whether the consumption of this water as part of the usual diet, reduces cardiometabolic risk factors in adult men and women.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 72
Inclusion Criteria
- Healthy adults, men and women >18 and ≤ 45 years
- Total-cholesterol > 200 mg/dL and < 300 mg/dL
Exclusion Criteria
- Age <18 and > 45 years
- Total-cholesterol ≥300 mg/dL
- Triglycerides > 250 mg/dL
- Total-cholesterol / HDL-cholesterol > 6
- Being a usual consumer of carbonic mineral water
- BMI < 20 and >30 kg/m2
- Diabetes
- Hypertension or digestive, liver or renal disease
- Eating disorders
- Being under medication that could affect lipid metabolism
- Consumption of functional foods that could affect lipid metabolism (food containing n-3 fatty acids or phytosterols)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Bicarbonated mineral water (BW) Mineral water Bicarbonated mineral water Control mineral water (CW) Mineral water Mineral water low in mineral content (control)
- Primary Outcome Measures
Name Time Method LDL-cholesterol 8 weeks
- Secondary Outcome Measures
Name Time Method Apolipoprotein A 8 weeks Total-cholesterol 8 weeks Triglycerides 8 weeks HDL-cholesterol 8 weeks Insulin 8 weeks Urine pH 8 weeks Serum aldosterone 8 weeks BMI 8 weeks Dietary protein intake 8 weeks Dietary fat intake 8 weeks Glucose 8 weeks Oxidized LDL 8 weeks Dietary energy intake 8 weeks Dietary cholesterol intake 8 weeks Apolipoprotein B 8 weeks Urine potassium 8 weeks Urine sodium 8 weeks Systolic Blood Pressure 8 weeks Diastolic Blood Pressure 8 weeks Dietary carbohydrate intake 8 weeks Urine creatinin 8 weeks Urine calcium 8 weeks