Intravenous Sodium Bicarbonate Verifies Intravenous Position of Catheters in Children
- Conditions
- Verifying the Correct Position of Intravenous Catheters
- Interventions
- Device: intravenous sodium bicarbonate
- Registration Number
- NCT01409083
- Lead Sponsor
- Sheba Medical Center
- Brief Summary
Sodium bicarbonate injected into a blood vessel transforms to carbon dioxide and water. The increase in carbon dioxide production can be detected by measuring the exhaled carbon dioxide in the lungs.
This study is conducted to access the clinical application of measuring exhaled carbon dioxide to verify the correct position of intravenous catheters.Once the catheter is in the correct position the injected bicarbonate will be detected as a distinct elevation of exhaled carbon dioxide. A similar study was already performed in adults and was found useful. The investigators now extend the clinical application to children.
- Detailed Description
Extravasation is the unintentional injection or leakage of fluids into the perivascular or subcutaneous space resulting in potential tissue injury. This prospective controlled study, will assesse the diagnostic utility of using intravenous diluted sodium bicarbonate to confirm placement of intravenous (IV) catheters in ventilated children. Diluted sodium bicarbonate will be created using undiluted standard 8.4% (1 meq/mL) sodium bicarbonate mixed in a 1:3 ratio with sterile water to achieve a final diluted concentration of 2.1% (0.25 mEq/mL). In 20 ASA I-II mechanically ventilated children age 2-8 years, the effects of 1 ml/kg of diluted 2.1% sodium bicarbonate or 0.9% normal saline,injected in a randomized order, will be analyzed. All children will have venous blood samples taken prior to injection and 10 minutes after injection for analysis of venous blood pH and electrolytes.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 18
- ASA I,II
- age 2-8 years
- ASA III or higher
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description intravenous bicarbonate intravenous sodium bicarbonate Diluted sodium bicarbonate will be injected to s new IV catheter expecting a rise in end-tidal CO2 control intravenous sodium bicarbonate equal volume of normal saline will be randomely injected
- Primary Outcome Measures
Name Time Method increase in exhaled carbon dioxide 0.5-10.00 seconds
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Sheba Medical Center
🇮🇱Ramat Gan, Israel