se of Sodium Bicarbonate Among Patients Undergoing Emergency Laparotomy
Not Applicable
Completed
- Conditions
- Health Condition 1: K566- Other and unspecified intestinal obstruction
- Registration Number
- CTRI/2021/09/037001
- Lead Sponsor
- PGIMER Chandigarh
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 90
Inclusion Criteria
1.Age group 18-60yrs
2.Diagnosed case of perforation peritonitis requiring emergency laparotomy surgery
Exclusion Criteria
1. Patient refusal
2. Inability to give informed consent
3. Pre-existing CKD on dialysis
4. Patients who are on oral bicarbonate therapy or have received bicarbonate in the last 24 hours
5. Critically ill patient with profound hemodynamic Instability requiring more than one vasopressor support
6. Patient with severe acidosis (Ph less than 7.0)
7. Pre-existing Alkalosis Ph more than 7.45 or HCO3 more than 26 mEq/L
8. Uncontrolled Diabetes Mellitus
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the difference in base excess (BE) between the patients receiving isotonic sodium bicarbonate or Ringer lactate at the end of surgeryTimepoint: At baseline,every hour during surgery, at the end of surgery, 1,6,24 and 72 hours after surgery
- Secondary Outcome Measures
Name Time Method To compare between the two groups: <br/ ><br>1.The pH, pCO2, Anion Gap, Lactate and blood sugars at baseline, every hour during surgery, at the end of the surgery, 1hour,12 hours and 24 hours after surgery <br/ ><br> 2. Duration of mechanical ventilation in the postoperative period <br/ ><br> 3. Incidence of re-exploration <br/ ><br> 4. Incidence of AKI within 7 days by KDIGO guidelines <br/ ><br> 5. Need of vasopressors in the perioperative period. <br/ ><br> 6. Duration of ICU and hospital stay <br/ ><br> 7. In-hospital mortality <br/ ><br>Timepoint: From the start of surgery till the discharge from hospital