A Clinical Study to evaluate the Rakta Stambhana effect of Yavanyadi Churna & Nagkeshara Churna in the management of Raktasrava with special reference to Anal Bleed

Phase 1/2

Not yet recruiting

Conditions: Disease of digestive system, unspecified. Ayurveda Condition: RAKTASRAVAH,

Registration Number: CTRI/2023/06/054286

Lead Sponsor: BVVS Ayurved Medical College and Hospital

Brief Summary: Bleeding per rectum is the commonest but alarming symptom of all the anorectal complaints of the patients. Acute overt Lower Gastro-Intestinal Bleed (LGIB) accounts for approximately 20% of all cases of GI Bleed1.

Rectal bleeding has a prevalence of 14% to 19% in adults1. 44.9% of general practitioner referrals for colonoscopy presenting rectal bleed found serious abnormalities. Since rectal bleeding is a cardinal symptom of many colorectal diseases including colorectal cancers, haemorrhoids, fissure in ano, fistula in ano, etc1. 1st and 2nd degree haemorrhoids present with bleeding- splash in the pan (bright red in colour), and mass per anum (2nd degree haemorrhoids)2. while Acute fissure-in-ano features as bleeding (dropwise or streak along the stool), pain and constipation3.

In classics *Pittaja* and *Raktaja* varieties of *Gudagata Rogas* having bleeding per rectum as the commonest symptom. *Gudagata Raktasrava* is mainly noted in *Pittaja Arsha* and *Raktaja* *Arsha* associated with *Daha* and *Avagadha Pureesha*4, while *Parikartika* is also due to *Pittaprakopa* presenting with *Tivarashoola* and *Raktasrava* from *Gudpradesha5*.

In classics we get various treatment modalities for *Gudagata Vikara* associated with *Raktasrava*. Acharya Vagbhata has mentioned about *Yavanyadi Churna,* which is indicated in the management of *Atishonita Pravrutti* (Profuse Bleed)6, whereas *Nagakeshara Churna* is said to be act as *Shonita Sthapana* in *Bhavaprakash Nighantu7*.

*Yavanyadi Churna* ingredients are *Yavani, Indrayava, Patha, Bilwa, Shunthi, Rasanjana* and all are having properties like *Katu, Tikta, Kashaya Rasa* which leads to *Kaphashamana* and *Raktasthambhana*, *Ushna* *Veerya* and *Katu* *Vipaka* leads to *Kaphashamana, Aamapachana* and *Agnideepana8*. *Nagakeshara Churna* having properties of *Kashaya Tikta Rasa*, *Laghu Ruksha* *Guna, Katu Vipaka, Sheetoshna Veerya* and works as *Kaphapittashamaka* which is said to be act as *Shonita Sthapana7.*

As both *Yavanyadi Churna* and *Nagakeshara Churna* are indicated for *Shonita Sthapana*, Hence the present study in undertaken to evaluate the *Rakta Stambhana* effect of *Yavanyadi Churna* and *Nagakeshara Churna* in the management of AnalBleed.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 40

Inclusion Criteria

Raktasrava (Bleed per rectum) Daha (Burning sensation) Shoola (Pain) Avagadha pureesha (Hard stool).

Exclusion Criteria

Patients suffering from Bleeding Disorders like- Anal polyp Prolapsed rectum Ulcerative colitis Crohnâ€™s disease Carcinoma of rectum and anus Infectious disease like RVD, HBsAg Pregnant and Lactating women.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Rakta Stambhana effect of Yavanyadi Churna in the management of Raktasrava.	10 Days

Secondary Outcome Measures

Name	Time	Method
Rakta Stambhana effect of Nagakeshara Churna in the management of Raktasrava.	10 Days
To Compare the Rakta Stambhana effect of Yavanyadi Churna & Nagkeshara Churna in the management of Raktasrava.	10 Days

Trial Locations

Locations (1): BVVS Ayurved Medical College and Hospital
🇮🇳
Bagalkot, KARNATAKA, India
BVVS Ayurved Medical College and Hospital
🇮🇳Bagalkot, KARNATAKA, India
Dr Saurabh Banjare
Principal investigator
7879992813
saurabhbanjare58@gmail.com