Evaluation of Postoperative Analgesic Efficacy of Ultrasound-Guided Rectus-Intercostal Fascial Plane Block in Living Liver Donors
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 64
- 试验地点
- 1
- 主要终点
- Morphine consumption
研究概览
简要总结
Postoperative pain control plays a crucial role in enhancing recovery and improving early mobilization in living liver donors. The rectus-intercostal fascial plane (RIFP) block is a novel ultrasound-guided regional anesthesia technique that provides anterior abdominal wall analgesia by targeting the intercostal nerves between the rectus abdominis and intercostal muscle fascia.
This prospective, randomized controlled clinical study aims to evaluate the postoperative analgesic efficacy and opioid-sparing effects of the RIFP block compared with standard intravenous analgesia in living liver donors undergoing donor hepatectomy.
Participants will be randomly assigned to two groups:
Group 1 (RIFP Block): Patients receiving an ultrasound-guided rectus-intercostal fascial plane block using 20 mL of 0.25% bupivacaine at the end of surgery, in addition to standard IV PCA (morphine).
Group 2 (Control): Patients receiving only standard IV PCA (morphine) without regional block.
详细描述
This prospective randomized controlled study will include living liver donors undergoing donor hepatectomy. Participants will be divided into two groups: the Rectus-Intercostal Fascial Plane (RIFP) Block Group and the Control Group.
In the RIFP group, patients will receive an ultrasound-guided RIFP block at the end of surgery and postoperative analgesia with intravenous morphine PCA. The control group will receive only intravenous morphine PCA without any regional block.
The primary outcome is total morphine consumption during the first 24 postoperative hours.
Secondary outcomes include pain scores at 1, 6, 12, and 24 hours, time to first rescue analgesia, amount of rescue analgesic used, and incidence of postoperative nausea and vomiting.
This study aims to evaluate the postoperative analgesic efficacy and opioid-sparing effect of the RIFP block in living liver donors compared with standard intravenous analgesia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age between 18 and 75 years
- •Patients with American Society of Anesthesiology (ASA) physical status I-II
- •Patients scheduled for a living donor hepatectomy
排除标准
- •Allergy to local anesthetics
- •Coagulopathy
- •Skin infection at the block area
- •Advanced renal failure
- •Chronic pain syndromes
- •Alcohol or drug abuse
- •Psychiatric disorders
研究组 & 干预措施
Rectus Intercostal Plane Block Group
Rectus Intercostal Plane Block Group The patients in the Rectus Intercostal Plane Block group will receive a bilateral rectus intercostal plane block and patient-controlled analgesia (PCA) with morphine for postoperative analgesia.
干预措施: Rectus Intercostal Plane Block (Other)
Control Group
The patients in the Control group will not receive any regional block and will receive PCA with morphine for postoperative analgesia.
干预措施: Control (No Block) (Other)
结局指标
主要结局
Morphine consumption
时间窗: Postoperative 24 hours
The amount of morphine required by the patient and given by the device will be recorded for the first 24 hours.
次要结局
- Postoperative visual analog scale scores(Postoperative 24 hours)
- Rescue analgesic drug consumption(postoperative 24 hours)
- Incidence of postoperative nausea and vomiting(postoperative 24 hours)