The Effects of Optimizing Post-operative Pain Management With Multi Modal Analgesia on Immune Suppression and Oncologic Outcome in Patients Undergoing Laparoscopic Colorectal Surgery
Overview
- Phase
- Not Applicable
- Intervention
- IV ketamine/lidocaine/IV PCA apply
- Conditions
- Laparoscopic Colorectal Resection Due to Cancer
- Sponsor
- Yonsei University
- Locations
- 1
- Primary Endpoint
- natural killer cell cytotoxicity
- Status
- Withdrawn
- Last Updated
- 6 years ago
Overview
Brief Summary
Traditionally, pain control methods based on narcotic analgesics have been used to control severe pain after surgery, but this has resulted in side effects such as vomiting, constipation, dizziness, mental confusion due to drugs, and respiratory depression. This slowed the recovery of the patient after surgery and increased the duration of hospitalization, which had a negative impact on the patient 's prognosis. In addition, research has been conducted on the use of various painkillers in a variety of ways over the past decade to reduce the dose of narcotic analgesics and to increase the effectiveness of pain control, since studies of anesthetics and narcotic analgesics have shown immunosuppressive effects.
This study investigate the effect of multimodal analgesics for postoperative pain control on immune function amd prognosis in patients undergoing laparoscopic colorectal cancer resection.
Investigators
Eligibility Criteria
Inclusion Criteria
- •elective laparoscopic colorectal resection due to colorectal cancer
- •curative, resectable operation
- •ASA classification Ⅰ-Ⅲ
Exclusion Criteria
- •elective co-operation due to distance metastasis
- •preoperative chemo/radiation therapy
- •drug allergy to opioid, tramadol, local anesthetics
- •MAOi medication (within 14 days of surgery)
- •decreased hepatic/renal function
- •Patients who can not read the consent form or are not fluent in Korean (illiterate, foreigner
- •pregnant, lactating women
- •palliative surgery
Arms & Interventions
IV ketamine/lidocaine/IV PCA (MA) group
In addition to basic anesthetic methods, multimodal analgesia with IV ketamine, lidocaine and IV PCA apply
Intervention: IV ketamine/lidocaine/IV PCA apply
IV PCA only (CA) group
In addition to basic anesthetic methods, only IC PCA apply for pain control
Intervention: IV PCA only apply
Outcomes
Primary Outcomes
natural killer cell cytotoxicity
Time Frame: postoperative day #3
Natural killer cell cytotoxicity is measured with NK Vue Kit™(ATGen, Gyeonggi-do, Korea).