Contrast Medium Volume and Contrast-induced Nephropathy After Percutaneous Coronary Intervention
试验速览
- 阶段
- 不适用
- 入组人数
- 2,000
- 试验地点
- 1
- 主要终点
- Contrast-Induced Nephropathy
研究概览
简要总结
To investigate the predictive value of the contrast media volume to creatinine clearance (V/CrCl) ratio for the risk of contrast-induced nephropathy (CIN) (i.e., within 48-72 h) and to determine a relatively safe V/CrCl cut-off value to avoid CIN in patients following PCI
详细描述
contrast media volume to creatinine clearance (V/CrCl) ratios were obtained from consecutive consenting patients after unselective PCI. Receiver-operator characteristic (ROC) curves were used to identify the optimal sensitivity for the observed range of V/CrCl. The predictive value of V/CrCl for the risk of CIN was assessed using multivariate logistic regression.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 21 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients who agreed to stay in the hospital for 2-3 days after percutaneous coronary intervention
- •provided written informed consent
- •Creatinine Clearance:15-60ml/min
排除标准
- •pregnancy
- •lactation
- •intravascular administration of an contrast medium within the previous seven days
- •treatment with metformin
- •aminoglycosides
- •N-acetylcysteine (NAC)
- •nonsteroidal anti-inflammatory drugs within the previous 48 h
- •intake of nephrotoxic drugs within the previous seven days
- •history of serious reactions to contrast mediums
- •severe concomitant disease
- •renal transplantation , or end-stage renal disease necessitating dialysis patients who died during percutaneous coronary intervention
结局指标
主要结局
Contrast-Induced Nephropathy
时间窗: 48-72 h
Contrast-Induced Nephropathy was defined as an increase in serum creatinine of more than 0.5 mg/dl from the baseline within 48-72 h of contrast exposure
次要结局
- Major adverse clinical events(1 year)