PREdictive Value of COntrast voluMe to creatinINe Clearance Ratio
- Conditions
- Contrast Induced Nephropathy
- Registration Number
- NCT01400295
- Lead Sponsor
- Guangdong Provincial People's Hospital
- Brief Summary
To determine a relatively safe contrast media volume to creatinine clearance cut-off value to avoid contrast-induced nephropathy in patients following coronary angiography
- Detailed Description
Contrast media volume to creatinine clearance (V/CrCl) ratios were obtained from consecutive consenting patients after coronary angiography. Receiver-operator characteristic (ROC) curves were used to identify the optimal sensitivity for the observed range of V/CrCl. The predictive value of V/CrCl for the risk of contrast-induced nephropathy was assessed using multivariate logistic regression.Subgroup analysis was performed on patients with creatinine clearance \< 60 ml/min,diabetes,emergent angiography.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 3000
- patients who agreed to stay in the hospital for 2-3 days after coronary angiography
- provided written informed consent
- pregnancy
- lactation
- intravascular administration of an contrast medium within the previous seven days
- treatment with metformin,aminoglycosides,N-acetylcysteine (NAC),nonsteroidal anti-inflammatory drugs within the previous 48 h
- intake of nephrotoxic drugs within the previous seven days
- history of serious reactions to contrast mediums, severe concomitant disease renal transplantation , or end-stage renal disease necessitating dialysis
- patients who died during coronary angiography
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Contrast-Induced Nephropathy 48-72 h Contrast-Induced Nephropathy was defined as an increase in serum creatinine of more than 0.5 mg/dl from the baseline within 48-72 h of contrast exposure
- Secondary Outcome Measures
Name Time Method Major adverse clinical events 1month Major adverse clinical events: death, requiring renal replacement therapy, 2nd myocardial infarction,target revascularization,acute heart failure, mechanical ventilation,2nd angina,tachyarrhythmia,hypotension,intra-aortic balloon pump and stroke
An early abnormal increase in serum creatinine 24h An early abnormal increase in serum creatinine defined as an increase in serum creatinine of more than 0.5 mg/dl from the baseline within 24h of contrast exposure
An early abnormal increase in serum cystatin C 24h An early abnormal increase in serum cystatin C was defined as an increase more than 10% from the baseline within 24h of contrast exposure
Trial Locations
- Locations (1)
Guangdong Cardiovascular Institute,Guangdong General Hospital
🇨🇳Guangzhou, Guangdong, China