Risk of Atherosclerotic Cardiovascular Disease in Childhood and Teen-age Onset Diabetes
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Atherosclerotic Cardiovascular Disease
- Sponsor
- Shanghai Jiao Tong University School of Medicine
- Enrollment
- 300
- Locations
- 1
- Primary Endpoint
- Occurrence of Atherosclerotic Cardiovascular Disease(ASCVD) high risk rating
- Status
- Not yet recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
For children and adolescents with diabetes, the pathological process of atherosclerotic cardiovascular disease(ASCVD) can exist in early childhood and progress rapidly to subclinical ASCVD. This study intends to explore the models for the prediction of ASCVD risk in childhood and teen-age onset diabetes with different types.
Detailed Description
Atherosclerotic cardiovascular disease (ASCVD) is the main cause of death in patients with diabetes. Currently recognized ASCVD risk assessment models are limited to adults with diabetes, but for children and adolescents with diabetes, the pathological process of ASCVD can exist in early childhood and progress rapidly to subclinical ASCVD. To sum up, this study intends to evaluate the high risk rate of ASCVD calculated by the traditional QRISK3 model and its correlation with the occurrence of subclinical ASCVD events through long-term follow-up of the natural history of diabetes onset in children and adolescents, and to explore the models for the prediction of ASCVD risk in childhood and teen-age onset diabetes with different types. This study aims to help block the pathological process of ASCVD in early duration, thereby reducing the occurrence of ASCVD in childhood and teen-age onset diabetes.
Investigators
Weiqiong Gu
Risk of Atherosclerotic Cardiovascular Disease in Childhood and Teen-age Onset Diabetes
Shanghai Jiao Tong University School of Medicine
Eligibility Criteria
Inclusion Criteria
- •Diagnosis of type 1 diabetes or type 2 diabetes
- •Age of onset: \<18y
- •Enrollment age: ≥18y
- •Gender: male or female
- •Diabetes duration ≥ 5 years
Exclusion Criteria
- •Specific types of diabetes
- •Clinical diagnosis of diabetes is unknown, and it belongs to untyped diabetes
- •Pregnancy or lactation
- •Received glucocorticoids, immunosuppressants, non-glycemic biological agents, and cytotoxic drugs in the past 3 months; non-steroidal pain relievers or antibiotics used for more than 1 week continuously
- •Onset of acute complications of diabetes in the past 3 months
- •Major trauma and surgery history in the past 3 months
Outcomes
Primary Outcomes
Occurrence of Atherosclerotic Cardiovascular Disease(ASCVD) high risk rating
Time Frame: 5 years
Risk value calculated by QRISK3 model \>10% (The QRISK®3-2018 risk calculator https://qrisk.org/three)
Secondary Outcomes
- Occurrence of subclinical ASCVD(carotid intima-media thickness)(5 years)
- Occurrence of subclinical ASCVD(coronary artery calcium)(5 years)
- Occurrence of subclinical ASCVD(carotid plaque)(5 years)
- Occurrence of subclinical ASCVD(pulse wave velocity)(5 years)