Prevalence of Oxidative Stress, Endothelial Dysfunction, Increased Carotid Artery Intima-media Thickness (cIMT) and Biomarkers of Vascular Inflammation in Adolescents With Type-1 Diabetes Mellitus (T1DM)
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Type 1 Diabetes Mellitus
- Sponsor
- Children's Mercy Hospital Kansas City
- Enrollment
- 51
- Locations
- 1
- Primary Endpoint
- Determine the impact of glycemic control on vascular oxidative stress/inflammation in adolescents with Type 1 diabetes mellitus
- Status
- Completed
- Last Updated
- 14 years ago
Overview
Brief Summary
The purpose of this study is to find out if diabetes damages the blood vessels of adolescents with good diabetes control compared to adolescents with less optimal control.
Detailed Description
Many published studies reveal that adult patients with T1DM can have early, silent and more advanced vessel wall thickness than normal subjects. This is influenced by the degree of their blood sugar control. If this is happening in adolescents, we want to know what proportion of adolescent children with type 1 diabetes show signs of early blood vessel damage. We also want to learn if these signs of damage are linked to other factors such as how long someone has had diabetes, blood sugar control or individual differences because of a difference in genetic make-up.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Adolescents ages 12-18 years
- •Tanner stage III-V
- •T1DM \> 2 years
- •HgbA1c \<8 or \>10 for previous 2 years
Exclusion Criteria
- •Subjects with known history of hypercholesterolemia or family history of hypercholesterolemia
- •Family history of premature cardiovascular disease
- •Hypertension defined as subjects with blood pressure greater than the 90th percentile for age
- •Anemia defined as Hgb \<11.0 g/dl
- •Congenital heart disease
- •Pituitary tumor
- •Known allergy to ultrasound gel
- •Recent head injury
- •Chromosomal abnormalities
Outcomes
Primary Outcomes
Determine the impact of glycemic control on vascular oxidative stress/inflammation in adolescents with Type 1 diabetes mellitus
Time Frame: 1 year
Secondary Outcomes
- To determine the impact of glycemic control and vascular oxidative stress/inflammation on vascular health in adolescents with T1DM(1 year)