Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
试验速览
- 阶段
- 不适用
- 入组人数
- 280
- 试验地点
- 1
- 主要终点
- parahthyroid hormone gradient by comparing between grafted and non-grafted forearm
研究概览
简要总结
The functional parathyroid auto-transplantation (PA) could release parathyroid hormone (PTH) into the circulatory system of the body through the capillaries. But when parathyroid glands were auto-grafted in the sternocleidomastoid muscle, it would be inconvenient to detect PTH to examine whether the graft functions. So the investigators took the forearm as the aim place for auto-transplantation, either subcutaneous or brachioradialis, with its relatively fixed - antecubital vein blood test which is simple. The survival criteria is assumed as the PTH gradient of 1.5 times or greater through comparing the bilateral PTH value in grafted and not-grafted forearm.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 10 Years 至 80 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with indications for PA treatment during cervical surgery
排除标准
- •patients suffering secondary hypoparathyroidism with forearm fistulization
研究组 & 干预措施
new site for parathyroid auto-graft
choose the site fairly close to the antecubital vein for parathyroid auto-transplantation
干预措施: injection with a syringe in new-site for parathyroid autografting (Procedure)
traditional parathyroid autograft
choose not intensely close to antecubital vein for parathyroid auto-transplantation
干预措施: injection with a syringe in traditional site for parathyroid autografting (Procedure)
结局指标
主要结局
parahthyroid hormone gradient by comparing between grafted and non-grafted forearm
时间窗: 1 months, 3 months and 6 months
The survival criteria is that the gradient of parathyroid hormone reaches 1.5 time or greater by comparing between grafted and non-grafted forearm
次要结局
- hypoparathyroidism: parathyroid hormone less than 15pg/ml(range from 15 to 65pg/ml)(6 months)
研究者
Gaosong Wu
Doctor, Professor
Tongji Hospital