Impact of glucose-6-phosphate dehydrogenase deficiency on dengue infection in Myanmar childre
Not Applicable
Completed
- Conditions
- suspected dengue
- Registration Number
- TCTR20180720001
- Lead Sponsor
- Mahidol-Norway Capicity building scholarship, 2014
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 212
Inclusion Criteria
1.2-13 years old children at Yankin Children Hospital with history of fever for 2-7 days with suspected dengue by paediatrician
2.Children with positive NS1 and/or IgM by Rapid diagnostic Test for Dengue
3.Children who are willing to participate with an informed consent or assent form
Exclusion Criteria
1. Children who have diagnosis other than Dengue (e.g. Malaria, Enteric fever, Central Nervous System infections, Respiratory tract infections, Gastrointestinal tract infections )
2. Children who have evidence of co-infections on admission
3. Children with immunocompromised status (e.g. Taking steroids, chemotherapy, malignancy, HIV, chronic organic diseases)
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Prevalence of G6PD deficiency among children with Dengue infection 01/09/2015 -30/09/2016 spectrophotometry method
- Secondary Outcome Measures
Name Time Method clinical presentations, severity and viral load in children with Dengue infection 01/09/2015 -30/6/2017 WHO 2009 Dengue classification, Dengue PCR, ELISA,relationship between clinical severity, viral load and G6PD status 01/10/2016 -30/6/2017 statistical analysis,G6PD gene mutation among Myanmar children. 10/10/2016-9/11/2016 real-time PCR