Influence of glucose degradation products on residual renal function in peritoneal dialysis (PD) patients

Completed

• Conditions: End-stage renal disease; Urological and Genital Diseases; Renal disease

• Registration Number: ISRCTN71335154
• Lead Sponsor: Gambro Corporate Research (Germany)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2006-03-23
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

1. End-stage renal disease
2. Treatment with PD
3. Age =18 years
4. Residual renal function =3 ml/min or creatinine clearance =6 ml/min
5. Negative serology for hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV)
6. Written informed consent

Exclusion Criteria

1. Pregnancy and lactation
2. Age >80 years
3. Multiple peritonitis episodes
4. Active malignancy

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Time response of residual renal function

Secondary Outcome Measures

Name	Time	Method
1. Peritoneal membrane transport parameters<br>2. CA 125 in effluent as marker for mesothelial cell mass/viability<br>3. Records of routine blood analyses, hospitalisation, peritonitis episodes, blood pressure