Investigating the effect of Butyrate on inflammatory genes and apoptosis in Ulcerative colitis
- Conditions
- lcerative Colitis Inflammation.Ulcerative colitis
- Registration Number
- IRCT20221215056828N1
- Lead Sponsor
- Shiraz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 30
Male or female 18 to 60 years old
Body mass index between 18.5 and 30
Estimating the severity of the disease based on the Mayo
The severity of the disease is mild to moderate
Patients with ulcerative colitis diagnosed by colonoscopy
Informed consent from the patient
Patients who are in the quiescent stage of the disease are included in the study, and patients who are in the acute stage of the disease are excluded.
The patient should refrain from any self treatment and use of herbal medicines.
Patients with other gastrointestinal diseases including intestinal obstruction, fistula, celiac disease, cancer and infectious diseases
Pregnancy and breastfeeding
Use of antibiotic drugs and other probiotic products and vitamin and mineral supplements for the previous 2 months.
History of hospitalization in the last 3 months
Type 2 diabetes patients
Acute stage of the disease
Change in the process of drug consumption during the study
Intensification of the disease during study
The place of implementation of the study is Faqihi Hospital and Motahari Clinic of Shiraz University of Medical Sciences
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Changes in gene Sirt1 expression. Timepoint: At the beginning of the study and 3 months later (the end of the study). Method of measurement: Real time PCR.
- Secondary Outcome Measures
Name Time Method ife quality score. Timepoint: At the beginning of the study and 3 months later (the end of the study). Method of measurement: IBDQ9 questionnaire.