Exercise Endurance Time on the 2nd Day at 2500 m High Altitude
- Conditions
- High Altitude Pulmonary Hypertension
- Interventions
- Procedure: High altitude exposureProcedure: Low altitude exposure
- Registration Number
- NCT05131737
- Lead Sponsor
- University of Zurich
- Brief Summary
The impact of a sojourn at 2500 m of high altitude for 26-30 h on constant work-rate exercise test time in patients with precapillary pulmonary hypertension
- Detailed Description
Patients with pulmonary hypertension will perform a constant work-rate exercise test at low altitude (450m) and at high altitude 2500m in a randomized-cross-over sequence protocol. The constant work-rate exercise test time and other measures will be assessed
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 28
- Informed consent as documented by signature
- PH class I (PAH) or IV (CTEPH) diagnosed according to guidelines: mean pulmonary artery pressure >20 mmHg, pulmonary vascular resistance ≥3 wood units, pulmonary arterial wedge pressure ≤15 mmHg during baseline measures at the diagnostic right-heart catheterization
- resting partial pressure of oxygen <8 kilopascal at Zurich at 490 m low altitude
- exposure to an altitude >1000 m for ≥3 nights during the last 2 weeks before the study
- inability to follow the procedures of the study
- other clinically significant concomitant end-stage disease (e.g., renal failure, hepatic dysfunction)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Constant work-rate at altitude 470 m above sea level (low altitude) High altitude exposure Cycling at low altitude Constant work-rate at altitude 2500 m above sea level (high altitude) High altitude exposure Cycling at high altitude Constant work-rate at altitude 2500 m above sea level (high altitude) Low altitude exposure Cycling at high altitude Constant work-rate at altitude 470 m above sea level (low altitude) Low altitude exposure Cycling at low altitude
- Primary Outcome Measures
Name Time Method cycle constant work-rate exercise test 30 hours Difference in cycle constant work-rate exercise test (CWRET) time at 2500 vs. 490 m (Time Frame 24 to 30 hours)
- Secondary Outcome Measures
Name Time Method Oxygen uptake 30 hours Difference in cardiorespiratory measurements: oxygen uptake, during a cycle constant work-rate exercise test (CWRET) time at high altitude vs. low altitude
Visual analogue scale 30 hours Difference in baseline in symptoms assessed by the Visual Analogue Scale at high altitude vs. low altitude
sit-to-stand test frequency 30 hours Difference in baseline in sit-to-stand test frequency of standing up from a chair in a minute at high altitude vs. low altitude
Heart rate 30 hours Difference in cardiorespiratory measurements: Heart rate, during a cycle constant work-rate exercise test (CWRET) time at high altitude vs. low altitude
Ventilation in liters per minute 30 hours Difference in cardiorespiratory measurements: Ventilation assessed in liters per minute, during a cycle constant work-rate exercise test (CWRET) time at high altitude vs. low altitude
Oxygen saturation 30 hours Difference in cardiorespiratory measurements: Oxygen saturation, during a cycle constant work-rate exercise test (CWRET) time at high altitude vs. low altitude
Partial pressure or oxygen 30 hours Difference in partial pressure of oxygen at the beginning and end of a cycle constant work-rate exercise test (CWRET) time at high altitude vs. low altitude
Borg dyspnoea scale 30 hours Difference in post-exercise Borg dyspnoea and leg fatigue scale during a cycle constant work-rate exercise test (CWRET) time at high altitude vs. low altitude
Tricuspid pressure gradient 30 hours Trans-tricuspid pressure gradient by echocardiography
6 minute walk test 30 hours Difference in baseline in 6 minute walk test distance at high altitude vs. low altitude
Trial Locations
- Locations (1)
University Hospital of Zurich
🇨🇭Zurich, Switzerland