Effects of Expiratory Pressure on Arterial Oxygenation During Hypoxia

• Conditions: Hypoxia
• Interventions: Device: threshold PEEP

• Registration Number: NCT01260428
• Lead Sponsor: AGIR à Dom

Brief Summary

Altitude tolerance correlates with the level of oxygenation achieved. The aim of the present study is to investigate whether increased expiratory pressure within the thorax is able to improve oxygenation during hypoxic hypoxia.

Detailed Description

Two types of procedures will be tested in a random order, interspaced by resting periods : threshold PEEP set at 5,10 and 15 cm of water and pursed leap breathing.

Subjects will be tested at rest, and during light exercise (30% of sea level predicted VO2max).

FiO2 will be set at 12.5% (4000 m). fc, VE, PETCO2, TA, ECG, cardiac output, and tissular oxygenation will be monitored.

Study Timeline

• Study First Submitted: 2010-12-14
• Study First Submitted QC: 2010-12-14
• Study First Posted: 2010-12-15
• Study Start: 2011-02
• Status Verified: 2012-02
• Last Update Submitted: 2012-02-27
• Last Update Posted: 2012-02-28

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 20

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
healthy active subjects	threshold PEEP	with and without high altitude intolerance

Primary Outcome Measures

Name	Time	Method
SpO2	mean over 1 minute	after three minutes of PEEP vs spontaneous breathing

Secondary Outcome Measures

Name	Time	Method
cardiac output	mean over 1 min	after three min of PEEP vs. spontaneous breathing
peripheral HbO2/DeoxyHb	1 min	after three minutes of PEEP / PLB vs. spontaneous breathing
pattern of breathing (fR, VT, PETCO2)	1 min	after three min of PEEP vs. spontaneous breathing

Trial Locations

Locations (1)

CHU de Grenoble; 🇫🇷 La Tronche, Isere, France