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Clinical Trials/NCT01992224
NCT01992224
Unknown
Not Applicable

Effect of Early Mechanical Ventilation to Severe Acute Pancreatitis

Ruijin Hospital1 site in 1 country2 target enrollmentJuly 2012

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Acute Pancreatitis
Sponsor
Ruijin Hospital
Enrollment
2
Locations
1
Primary Endpoint
Mechanical Ventilation Time
Last Updated
12 years ago

Overview

Brief Summary

Acute lung injury (ALI) and acute respiratory distress syndrome(ARDS) represent the most common and earliest organ dysfunction in acute pancreatitis, presenting as dyspnea and intractable hypoxemia, with secondary bilateral pulmonary infiltrates on radiograph. And mechanical ventilation (MV) is the essential intervention to improve oxygenation. When to initiate MV remains uncertain. In this study, we aim to compare the effect of early MV and conventional MV, and we hypothesize that early MV may be a better treatment option.

Registry
clinicaltrials.gov
Start Date
July 2012
End Date
June 2016
Last Updated
12 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Erzhen Chen

Professor

Ruijin Hospital

Eligibility Criteria

Inclusion Criteria

  • Diagnosis of pancreatitis:typical pain, increase in serum lipase or amylase, onset of abdominal pain within 72h before admission
  • The diagnosis criteria of Severe Acute Pancreatitis is according to Atlanta criteria revisited in 2012
  • the diagnosis of ARDS meets the criteria of Berlin definition

Exclusion Criteria

  • chronic respiratory disease as chronic obstructive pulmonary disease (COPD), asthma
  • organic cardiopathy
  • pregnancy

Outcomes

Primary Outcomes

Mechanical Ventilation Time

Time Frame: 28 days

Secondary Outcomes

  • the incidence of ventilation associated pneumonia(28 days)

Study Sites (1)

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