Renal function after pulsatile blood flow during cardiopulmonary bypass in cardiac surgery

Not yet recruiting

• Conditions: Cardiac surgery; Renal function; Cardiopulmonary bypass

• Registration Number: NL-OMON21086
• Lead Sponsor: VU University Medical CenterUMCG

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 11 June 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 294

Inclusion Criteria

Adult subjects with written informed consent (age 18-90 years) undergoing elective cardiac surgery with cardiopulmonary bypass; Patients with preoperative renal dysfunction (GFR <50 mL/min/1.73m2) or patients with diabetes mellitus and a GFR <60 mL/min/1.73m2 based on the CKD-EPI formula.

Exclusion Criteria

- Emergency operations;

- Patients with previous heart surgery;

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Relative change in serum creatinine levels in postoperative period

Secondary Outcome Measures

Name	Time	Method
Postoperative urine production in ml; <br /><br>Serum urea levels, creatinine clearance, glomerular filtration rate;<br /><br>Nadir DO2, DO2/VCO2 ratio; <br /><br>Sublingual microcirculatory perfused vessel density and perfused boundary region (n=40);<br /><br>Microcirculatory and tissue oxygenation O2C levels (n=40);<br /><br>Prevalence of renal replacement therapy<br>